caa a22 4500 445889225 CHVBK 20180317145610.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00535-010-0305-6 doi (NATIONALLICENCE)springer-10.1007/s00535-010-0305-6 A simple clinical scoring system using ferritin, fasting insulin, and type IV collagen 7S for predicting steatohepatitis in nonalcoholic fatty liver disease [Elektronische Daten] [Yoshio Sumida, Masato Yoneda, Hideyuki Hyogo, Kanji Yamaguchi, Masafumi Ono, Hideki Fujii, Yuichiro Eguchi, Yasuaki Suzuki, Shunsuke Imai, Kazuyuki Kanemasa, Koji Fujita, Kazuaki Chayama, Kohichiroh Yasui, Toshiji Saibara, Norifumi Kawada, Kazuma Fujimoto, Yutaka Kohgo, Takeshi Okanoue] Background: Liver histology is the gold standard for the diagnosis of nonalcoholic steatohepatitis (NASH). Noninvasive, simple, reproducible, and reliable biomarkers are greatly needed to differentiate NASH from nonalcoholic fatty liver disease (NAFLD). Methods: To construct a scoring system for predicting NASH, 177 Japanese patients with biopsy-proven NAFLD were enrolled. To validate the scoring system, 442 biopsy-proven NAFLD patients from eight hepatology centers in Japan were also enrolled. Results: In the estimation group, 98 (55%) patients had NASH. Serum ferritin [≥200ng/ml (female) or ≥300ng/ml (male)], fasting insulin (≥10μU/ml), and type IV collagen 7S (≥5.0ng/ml) were selected as independent variables associated with NASH, by multilogistic regression analysis. These three variables were combined in a weighted sum [serum ferritin ≥200ng/ml (female) or ≥300ng/ml (male)=1 point, fasting insulin ≥10μU/ml=1 point, and type IV collagen 7S ≥5.0ng/ml=2 points] to form an easily calculated composite score for predicting NASH, called the NAFIC score. The area under the receiver operating characteristic (AUROC) curve for predicting NASH was 0.851 in the estimation group and 0.782 in the validation group. The NAFIC AUROC was the greatest among several previously established scoring systems for detecting NASH, but also for predicting severe fibrosis. Conclusions: NAFIC score can predict NASH in Japanese NAFLD patients with sufficient accuracy and simplicity to be considered for clinical use. Springer, 2010 Iron overload nationallicence Hepatic fibrosis nationallicence Nonalcoholic steatohepatitis nationallicence Sumida Yoshio Center for Digestive and Liver Diseases, Nara City Hospital, Higashi Kidera-cho 1-50-1, 630-8305, Nara, Japan aut Yoneda Masato Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan aut Hyogo Hideyuki Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan aut Yamaguchi Kanji Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan aut Ono Masafumi Department of Gastroenterology and Hepatology, Kochi Medical School, Kochi, Japan aut Fujii Hideki Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka, Japan aut Eguchi Yuichiro Department of Internal Medicine, Saga Medical School, Saga University, Saga, Japan aut Suzuki Yasuaki Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical College, Asahikawa, Japan aut Imai Shunsuke Department of Pathology, Nara City Hospital, Nara, Japan aut Kanemasa Kazuyuki Center for Digestive and Liver Diseases, Nara City Hospital, Higashi Kidera-cho 1-50-1, 630-8305, Nara, Japan aut Fujita Koji Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan aut Chayama Kazuaki Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan aut Yasui Kohichiroh Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan aut Saibara Toshiji Department of Gastroenterology and Hepatology, Kochi Medical School, Kochi, Japan aut Kawada Norifumi Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka, Japan aut Fujimoto Kazuma Department of Internal Medicine, Saga Medical School, Saga University, Saga, Japan aut Kohgo Yutaka Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical College, Asahikawa, Japan aut Okanoue Takeshi Hepatology Center, Saiseikai Suita Hospital, Osaka, Japan aut Journal of Gastroenterology Springer Japan 46/2(2011-02-01), 257-268 0944-1174 46:2<257 2011 46 535 https://doi.org/10.1007/s00535-010-0305-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-010-0305-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sumida Yoshio Center for Digestive and Liver Diseases, Nara City Hospital, Higashi Kidera-cho 1-50-1, 630-8305, Nara, Japan aut NATIONALLICENCE 700 1- Yoneda Masato Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan aut NATIONALLICENCE 700 1- Hyogo Hideyuki Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan aut NATIONALLICENCE 700 1- Yamaguchi Kanji Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan aut NATIONALLICENCE 700 1- Ono Masafumi Department of Gastroenterology and Hepatology, Kochi Medical School, Kochi, Japan aut NATIONALLICENCE 700 1- Fujii Hideki Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka, Japan aut NATIONALLICENCE 700 1- Eguchi Yuichiro Department of Internal Medicine, Saga Medical School, Saga University, Saga, Japan aut NATIONALLICENCE 700 1- Suzuki Yasuaki Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical College, Asahikawa, Japan aut NATIONALLICENCE 700 1- Imai Shunsuke Department of Pathology, Nara City Hospital, Nara, Japan aut NATIONALLICENCE 700 1- Kanemasa Kazuyuki Center for Digestive and Liver Diseases, Nara City Hospital, Higashi Kidera-cho 1-50-1, 630-8305, Nara, Japan aut NATIONALLICENCE 700 1- Fujita Koji Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan aut NATIONALLICENCE 700 1- Chayama Kazuaki Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan aut NATIONALLICENCE 700 1- Yasui Kohichiroh Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan aut NATIONALLICENCE 700 1- Saibara Toshiji Department of Gastroenterology and Hepatology, Kochi Medical School, Kochi, Japan aut NATIONALLICENCE 700 1- Kawada Norifumi Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka, Japan aut NATIONALLICENCE 700 1- Fujimoto Kazuma Department of Internal Medicine, Saga Medical School, Saga University, Saga, Japan aut NATIONALLICENCE 700 1- Kohgo Yutaka Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical College, Asahikawa, Japan aut NATIONALLICENCE 700 1- Okanoue Takeshi Hepatology Center, Saiseikai Suita Hospital, Osaka, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/2(2011-02-01), 257-268 0944-1174 46:2<257 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer