caa a22 4500 445889241 CHVBK 20180317145610.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00535-010-0319-0 doi (NATIONALLICENCE)springer-10.1007/s00535-010-0319-0 Small bile duct involvement in IgG4-related sclerosing cholangitis: liver biopsy and cholangiography correlation [Elektronische Daten] [Itaru Naitoh, Yoh Zen, Takahiro Nakazawa, Tomoaki Ando, Kazuki Hayashi, Fumihiro Okumura, Katsuyuki Miyabe, Michihiro Yoshida, Shunsuke Nojiri, Takayoshi Kanematsu, Hirotaka Ohara, Takashi Joh] Background: IgG4-related sclerosing cholangitis (IgG4-SC) needs to be differentiated from primary sclerosing cholangitis (PSC). In this study, we performed a retrospective study to reveal cases in which liver needle biopsy was useful for differential diagnosis. Methods: Nineteen patients with IgG4-SC and 22 patients with PSC were studied. All patients underwent endoscopic retrograde cholangiography and liver needle biopsy. We defined small bile duct involvement of IgG4-SC histologically as damage to the small bile duct associated with infiltration of ≥10 IgG4+ plasma cells per high power field (HPF). Clinicopathological characteristics were compared between IgG4-SC patients with and without small bile duct involvement. Results: Small bile duct involvement was observed in 5 (26%) of the patients with IgG4-SC. Patients with small bile duct involvement showed a higher incidence of intrahepatic biliary strictures on cholangiography (80 vs. 21%, p=0.038). Conversely, 4 of 7 (57%) patients with intrahepatic biliary strictures on cholangiography had histologically evident small duct involvement. The number of IgG4+ plasma cells was significantly correlated with the site of the most proximal stricture on cholangiograms (p=0.021). The number of IgG4+ plasma cells per HPF was significantly higher in IgG4-SC patients with intrahepatic biliary strictures than in those with PSC (13.4 vs. 0.4cells/HPF, p<0.001). Conclusions: Involvement of small bile ducts is more frequent in patients with intrahepatic biliary strictures on cholangiography, and liver needle biopsy is especially useful for these patients. Springer, 2010 IgG4-related sclerosing cholangitis nationallicence Primary sclerosing cholangitis nationallicence Autoimmune pancreatitis nationallicence Liver biopsy nationallicence Cholangiogram nationallicence Naitoh Itaru Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut Zen Yoh Institute of Liver Studies, King's College Hospital, London, UK aut Nakazawa Takahiro Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut Ando Tomoaki Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut Hayashi Kazuki Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut Okumura Fumihiro Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut Miyabe Katsuyuki Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut Yoshida Michihiro Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut Nojiri Shunsuke Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut Kanematsu Takayoshi Department of Community-based Medical Education, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan aut Ohara Hirotaka Department of Community-based Medical Education, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan aut Joh Takashi Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut Journal of Gastroenterology Springer Japan 46/2(2011-02-01), 269-276 0944-1174 46:2<269 2011 46 535 https://doi.org/10.1007/s00535-010-0319-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-010-0319-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Naitoh Itaru Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut NATIONALLICENCE 700 1- Zen Yoh Institute of Liver Studies, King's College Hospital, London, UK aut NATIONALLICENCE 700 1- Nakazawa Takahiro Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut NATIONALLICENCE 700 1- Ando Tomoaki Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut NATIONALLICENCE 700 1- Hayashi Kazuki Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut NATIONALLICENCE 700 1- Okumura Fumihiro Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut NATIONALLICENCE 700 1- Miyabe Katsuyuki Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut NATIONALLICENCE 700 1- Yoshida Michihiro Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut NATIONALLICENCE 700 1- Nojiri Shunsuke Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut NATIONALLICENCE 700 1- Kanematsu Takayoshi Department of Community-based Medical Education, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan aut NATIONALLICENCE 700 1- Ohara Hirotaka Department of Community-based Medical Education, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan aut NATIONALLICENCE 700 1- Joh Takashi Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, 467-8601, Nagoya, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/2(2011-02-01), 269-276 0944-1174 46:2<269 2011 46 535 Metadata rights 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