caa a22 4500 445889268 CHVBK 20180317145610.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00535-011-0455-1 doi (NATIONALLICENCE)springer-10.1007/s00535-011-0455-1 Efficacy of pegylated interferon plus ribavirin combination therapy for hepatitis C patients with normal ALT levels: a matched case-control study [Elektronische Daten] [Naoki Hiramatsu, Yuko Inoue, Tsugiko Oze, Nao Kurashige, Takayuki Yakushijin, Kiyoshi Mochizuki, Takuya Miyagi, Tomohide Tatsumi, Shinichi Kiso, Tatsuya Kanto, Akinori Kasahara, Tetsuo Takehara, Masahide Oshita, Eiji Mita, Hideki Hagiwara, Yoshiaki Inui, Kazuhiro Katayama, Shinji Tamura, Harumasa Yoshihara, Yasuharu Imai, Norio Hayashi] Background: The antiviral effect of pegylated interferon (Peg-IFN) plus ribavirin combination therapy in chronic hepatitis C (CHC) patients with normal alanine aminotransferase (ALT) levels (N-ALT) has been reported to be equivalent to that for patients with elevated ALT levels (E-ALT). However, the actual antiviral effect in N-ALT patients remains obscure because efficacy can be overestimated in patients with an advantageous background. Methods: In this study, 386 patients were extracted, for a matched case-control study, from 1320 CHC patients treated with Peg-IFN alpha-2b plus ribavirin combination therapy; 193 N-ALT patients [116 with hepatitis C virus genotype 1 (HCV-1), 77 with HCV genotype 2 (HCV-2)] were matched with 193 E-ALT patients by a propensity score method using the variables of age, sex, IFN treatment history, body mass index, and platelet counts. Results: On multivariate analysis for sustained virological response (SVR) in N-ALT patients, younger age, low HCV RNA level at baseline, and HCV-2 were significant factors. The matched case-control study showed that the SVR rates of N-ALT patients were equivalent to those of E-ALT patients; at 49 and 40% in the HCV-1 group (P=0.146), and 78 and 81% in the HCV-2 group (P=0.691). However, in N-ALT patients with non-SVR, approximately 40% showed ALT elevation at 24weeks post-treatment. Conclusion: Our findings indicate that the antiviral effect of Peg-IFN plus ribavirin therapy in N-ALT patients is comparable to that for E-ALT patients irrespective of their advantageous background; however, the application of this therapy for N-ALT patients, especially for those with HCV-1, should be considered carefully. Springer, 2011 Hepatitis C virus nationallicence Normal alanine aminotransferase nationallicence Pegylated interferon plus ribavirin combination therapy nationallicence Propensity score method nationallicence Matched case-control study nationallicence Hiramatsu Naoki Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Inoue Yuko Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Oze Tsugiko Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Kurashige Nao Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Yakushijin Takayuki Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Mochizuki Kiyoshi Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Miyagi Takuya Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Tatsumi Tomohide Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Kiso Shinichi Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Kanto Tatsuya Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Kasahara Akinori Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Takehara Tetsuo Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Oshita Masahide Osaka Police Hospital, Osaka, Japan aut Mita Eiji National Hospital Organization Osaka National Hospital, Osaka, Japan aut Hagiwara Hideki Kansai Rosai Hospital, Amagasaki, Japan aut Inui Yoshiaki Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Japan aut Katayama Kazuhiro Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan aut Tamura Shinji Minoh City Hospital, Minoh, Japan aut Yoshihara Harumasa Osaka Rosai Hospital, Sakai, Japan aut Imai Yasuharu Ikeda Municipal Hospital, Ikeda, Japan aut Hayashi Norio Kansai Rosai Hospital, Amagasaki, Japan aut Journal of Gastroenterology Springer Japan 46/11(2011-11-01), 1335-1343 0944-1174 46:11<1335 2011 46 535 https://doi.org/10.1007/s00535-011-0455-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0455-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hiramatsu Naoki Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Inoue Yuko Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Oze Tsugiko Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Kurashige Nao Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Yakushijin Takayuki Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Mochizuki Kiyoshi Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Miyagi Takuya Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Tatsumi Tomohide Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Kiso Shinichi Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Kanto Tatsuya Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Kasahara Akinori Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Takehara Tetsuo Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Oshita Masahide Osaka Police Hospital, Osaka, Japan aut NATIONALLICENCE 700 1- Mita Eiji National Hospital Organization Osaka National Hospital, Osaka, Japan aut NATIONALLICENCE 700 1- Hagiwara Hideki Kansai Rosai Hospital, Amagasaki, Japan aut NATIONALLICENCE 700 1- Inui Yoshiaki Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Japan aut NATIONALLICENCE 700 1- Katayama Kazuhiro Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan aut NATIONALLICENCE 700 1- Tamura Shinji Minoh City Hospital, Minoh, Japan aut NATIONALLICENCE 700 1- Yoshihara Harumasa Osaka Rosai Hospital, Sakai, Japan aut NATIONALLICENCE 700 1- Imai Yasuharu Ikeda Municipal Hospital, Ikeda, Japan aut NATIONALLICENCE 700 1- Hayashi Norio Kansai Rosai Hospital, Amagasaki, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/11(2011-11-01), 1335-1343 0944-1174 46:11<1335 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer