caa a22 4500 445889276 CHVBK 20180317145610.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00535-011-0443-5 doi (NATIONALLICENCE)springer-10.1007/s00535-011-0443-5 SOX9 is expressed in normal stomach, intestinal metaplasia, and gastric carcinoma in humans [Elektronische Daten] [Miho Sashikawa Kimura, Hiroyuki Mutoh, Kentaro Sugano] Background: SOX9 is a marker for stem cells in the intestine and overexpression of SOX9 is found in some types of cancer. However, the expression of SOX9 in normal stomach, precancerous intestinal metaplasia, and gastric carcinoma has not yet been clarified. This study aimed to investigate SOX9 expression in the corpus and pyloric regions of the normal human stomach, premalignant intestinal metaplasia, and gastric carcinoma by using immunohistochemistry. Methods: We evaluated SOX9 expression in 46 clinical samples (early gastric well-differentiated adenocarcinoma including surrounding intestinal metaplasia) resected under esophagogastroduodenoscopy. Results: A small amount of SOX9 was expressed in the neck/isthmus of the corpus region and SOX9 expression was predominantly restricted to the neck/isthmus of the pyloric region in normal human stomach. In the intestinal metaplastic mucosa, SOX9- and PCNA-positive cells were located at the base of the intestinal metaplastic mucosa. Almost all of the gastric carcinoma cells expressed SOX9. Conclusion: SOX9 is expressed in intestinal metaplasia and gastric carcinoma in humans. Springer, 2011 SOX9 nationallicence Stomach nationallicence Intestinal metaplasia nationallicence Gastric carcinoma nationallicence Sashikawa Kimura Miho Division of Gastroenterology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Mutoh Hiroyuki Division of Gastroenterology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Sugano Kentaro Division of Gastroenterology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Journal of Gastroenterology Springer Japan 46/11(2011-11-01), 1292-1299 0944-1174 46:11<1292 2011 46 535 https://doi.org/10.1007/s00535-011-0443-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0443-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sashikawa Kimura Miho Division of Gastroenterology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Mutoh Hiroyuki Division of Gastroenterology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Sugano Kentaro Division of Gastroenterology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/11(2011-11-01), 1292-1299 0944-1174 46:11<1292 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer