caa a22 4500 445889306 CHVBK 20180317145610.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00535-011-0445-3 doi (NATIONALLICENCE)springer-10.1007/s00535-011-0445-3 Genetic variation in PLCE1 is associated with gastric cancer survival in a Chinese population [Elektronische Daten] [Dewei Luo, Yan Gao, Shizhi Wang, Meilin Wang, Dongmei Wu, Wei Wang, Ming Xu, Jianwei Zhou, Weida Gong, Yongfei Tan, Zhengdong Zhang] Background: Two genome-wide association studies on gastric cancer showed a previously unknown gastric cancer susceptible locus in PLCE1 at 10q23. We hypothesized that the single nucleotide polymorphism (SNP) rs2274223 A/G is associated with the survival rate of gastric cancer. Methods: We genotyped the above SNP in 940 gastric cancer patients to investigate the association between the polymorphism and gastric cancer survival by the TaqMan method. Results: We found that patients carrying PLCE1 rs2274223 AA genotype survived for a significantly shorter time than those carrying the AG and GG genotypes (log-rank P=0.046). This significance was enhanced in the dominant model (AA vs. AG/GG, log-rank P=0.014). Multivariate Cox regression analyses showed that the AG/GG genotypes were associated with a significantly decreased risk of death from gastric cancer [adjusted hazard ratio (HR)=0.79, 95% confidence interval (CI)=0.65-0.95]. Most of stratification analysis did not find an enhanced association between the same genotype and prognosis, except for patients with TNM stage III disease (HR=0.63, 95% CI=0.48-0.83). Conclusion: Our findings showed that the PLCE1 SNP rs2274223 was associated with significantly improved gastric cancer survival in a Chinese population. Further functional studies are needed to validate our results. Springer, 2011 PLCE1 nationallicence GWAS nationallicence Gastric cancer nationallicence Polymorphism nationallicence Survival nationallicence Luo Dewei Department of Molecular and Genetic Toxicology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, School of Public Health, Nanjing Medical University, 140 Hanzhong Road, 210029, Nanjing, China aut Gao Yan Department of Molecular and Genetic Toxicology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, School of Public Health, Nanjing Medical University, 140 Hanzhong Road, 210029, Nanjing, China aut Wang Shizhi Department of Molecular and Genetic Toxicology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, School of Public Health, Nanjing Medical University, 140 Hanzhong Road, 210029, Nanjing, China aut Wang Meilin Department of Occupational Medicine and Environmental Health, The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China aut Wu Dongmei Department of Occupational Medicine and Environmental Health, The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China aut Wang Wei Department of Molecular and Genetic Toxicology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, School of Public Health, Nanjing Medical University, 140 Hanzhong Road, 210029, Nanjing, China aut Xu Ming Department of Molecular and Genetic Toxicology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, School of Public Health, Nanjing Medical University, 140 Hanzhong Road, 210029, Nanjing, China aut Zhou Jianwei Department of Molecular Cell Biology and Toxicology, School of Public Health, Cancer Center, Nanjing Medical University, Nanjing, China aut Gong Weida Department of General Surgery, Yixing Cancer Hospital, Yixing, China aut Tan Yongfei Department of General Surgery, Yixing People's Hospital, Yixing, China aut Zhang Zhengdong Department of Molecular and Genetic Toxicology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, School of Public Health, Nanjing Medical University, 140 Hanzhong Road, 210029, Nanjing, China aut Journal of Gastroenterology Springer Japan 46/11(2011-11-01), 1260-1266 0944-1174 46:11<1260 2011 46 535 https://doi.org/10.1007/s00535-011-0445-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0445-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Luo Dewei Department of Molecular and Genetic Toxicology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, School of Public Health, Nanjing Medical University, 140 Hanzhong Road, 210029, Nanjing, China aut NATIONALLICENCE 700 1- Gao Yan Department of Molecular and Genetic Toxicology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, School of Public Health, Nanjing Medical University, 140 Hanzhong Road, 210029, Nanjing, China aut NATIONALLICENCE 700 1- Wang Shizhi Department of Molecular and Genetic Toxicology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, School of Public Health, Nanjing Medical University, 140 Hanzhong Road, 210029, Nanjing, China aut NATIONALLICENCE 700 1- Wang Meilin Department of Occupational Medicine and Environmental Health, The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China aut NATIONALLICENCE 700 1- Wu Dongmei Department of Occupational Medicine and Environmental Health, The Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China aut NATIONALLICENCE 700 1- Wang Wei Department of Molecular and Genetic Toxicology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, School of Public Health, Nanjing Medical University, 140 Hanzhong Road, 210029, Nanjing, China aut NATIONALLICENCE 700 1- Xu Ming Department of Molecular and Genetic Toxicology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, School of Public Health, Nanjing Medical University, 140 Hanzhong Road, 210029, Nanjing, China aut NATIONALLICENCE 700 1- Zhou Jianwei Department of Molecular Cell Biology and Toxicology, School of Public Health, Cancer Center, Nanjing Medical University, Nanjing, China aut NATIONALLICENCE 700 1- Gong Weida Department of General Surgery, Yixing Cancer Hospital, Yixing, China aut NATIONALLICENCE 700 1- Tan Yongfei Department of General Surgery, Yixing People's Hospital, Yixing, China aut NATIONALLICENCE 700 1- Zhang Zhengdong Department of Molecular and Genetic Toxicology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, School of Public Health, Nanjing Medical University, 140 Hanzhong Road, 210029, Nanjing, China aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/11(2011-11-01), 1260-1266 0944-1174 46:11<1260 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer