caa a22 4500 445889357 CHVBK 20180317145611.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00535-011-0436-4 doi (NATIONALLICENCE)springer-10.1007/s00535-011-0436-4 Platelet count for predicting fibrosis in nonalcoholic fatty liver disease [Elektronische Daten] [Masato Yoneda, Hideki Fujii, Yoshio Sumida, Hideyuki Hyogo, Yoshito Itoh, Masafumi Ono, Yuichiro Eguchi, Yasuaki Suzuki, Noriaki Aoki, Kazuyuki Kanemasa, Kento Imajo, Kazuaki Chayama, Toshiji Saibara, Norifumi Kawada, Kazuma Fujimoto, Yutaka Kohgo, Toshikazu Yoshikawa, Takeshi Okanoue] Background: The severity of liver fibrosis is known to be a good indicator for surveillance, and for determining the prognosis and optimal treatment of nonalcoholic fatty liver disease (NAFLD). However, it is virtually impossible to carry out liver biopsies in all NAFLD patients. The purpose of this study was to investigate the clinical usefulness of measuring the platelet count for predicting the severity of liver fibrosis in a large retrospective cohort of Japanese patients with NAFLD. Methods: A total of 1,048 patients with liver-biopsy-confirmed NAFLD seen between 2002 and 2008 were enrolled from nine hepatology centers in Japan. Laboratory evaluations were performed for all patients. Results: A linear decrease of the platelet count with increasing histological severity of hepatic fibrosis was revealed. The area under the receiver operating characteristic curve estimating the diagnostic performance of the platelet count for hepatic fibrosis Stage 3 was 0.774 (optimal cutoff value, 19.2×104/μl; sensitivity, 62.7%; specificity, 76.3%), and that for Stage 4 was 0.918 (optimal cutoff value, 15.3×104/μl; sensitivity, 80.5%; specificity, 88.8%). Conclusions: The platelet count may be an ideal biomarker of the severity of fibrosis in NAFLD patients, because it is simple, easy to measure and handle, cost-effective, and accurate for predicting the severity of fibrosis. Furthermore, by using the platelet count cutoff value validated in our multiple large trials, efficient recruitment of NAFLD patients may be facilitated. Springer, 2011 Nonalcoholic fatty liver disease nationallicence Platelet nationallicence Fibrosis nationallicence NAFLD : Nonalcoholic fatty liver disease nationallicence AST : Aspartate aminotransferase nationallicence ALT : Alanine aminotransferase nationallicence AUROC : Area under the receiver operating characteristic nationallicence BMI : Body mass index nationallicence APRI : Aspartate aminotransferase to platelet ratio index nationallicence Yoneda Masato Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan aut Fujii Hideki Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka, Japan aut Sumida Yoshio Center for Digestive and Liver Diseases, Nara City Hospital, Nara, Japan aut Hyogo Hideyuki Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan aut Itoh Yoshito Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan aut Ono Masafumi Department of Gastroenterology and Hepatology, Kochi Medical School, Kochi, Japan aut Eguchi Yuichiro Department of General Medicine, Saga Medical School, Saga, Japan aut Suzuki Yasuaki Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical College, Asahikawa, Japan aut Aoki Noriaki School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX, USA aut Kanemasa Kazuyuki Center for Digestive and Liver Diseases, Nara City Hospital, Nara, Japan aut Imajo Kento Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan aut Chayama Kazuaki Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan aut Saibara Toshiji Department of Gastroenterology and Hepatology, Kochi Medical School, Kochi, Japan aut Kawada Norifumi Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka, Japan aut Fujimoto Kazuma Department of General Medicine, Saga Medical School, Saga, Japan aut Kohgo Yutaka Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical College, Asahikawa, Japan aut Yoshikawa Toshikazu Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan aut Okanoue Takeshi Hepatology Center, Saiseikai Suita Hospital, Suita, Japan aut Journal of Gastroenterology Springer Japan 46/11(2011-11-01), 1300-1306 0944-1174 46:11<1300 2011 46 535 https://doi.org/10.1007/s00535-011-0436-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0436-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yoneda Masato Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan aut NATIONALLICENCE 700 1- Fujii Hideki Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka, Japan aut NATIONALLICENCE 700 1- Sumida Yoshio Center for Digestive and Liver Diseases, Nara City Hospital, Nara, Japan aut NATIONALLICENCE 700 1- Hyogo Hideyuki Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan aut NATIONALLICENCE 700 1- Itoh Yoshito Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan aut NATIONALLICENCE 700 1- Ono Masafumi Department of Gastroenterology and Hepatology, Kochi Medical School, Kochi, Japan aut NATIONALLICENCE 700 1- Eguchi Yuichiro Department of General Medicine, Saga Medical School, Saga, Japan aut NATIONALLICENCE 700 1- Suzuki Yasuaki Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical College, Asahikawa, Japan aut NATIONALLICENCE 700 1- Aoki Noriaki School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX, USA aut NATIONALLICENCE 700 1- Kanemasa Kazuyuki Center for Digestive and Liver Diseases, Nara City Hospital, Nara, Japan aut NATIONALLICENCE 700 1- Imajo Kento Division of Gastroenterology, Yokohama City University Graduate School of Medicine, Yokohama, Japan aut NATIONALLICENCE 700 1- Chayama Kazuaki Department of Medicine and Molecular Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan aut NATIONALLICENCE 700 1- Saibara Toshiji Department of Gastroenterology and Hepatology, Kochi Medical School, Kochi, Japan aut NATIONALLICENCE 700 1- Kawada Norifumi Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka, Japan aut NATIONALLICENCE 700 1- Fujimoto Kazuma Department of General Medicine, Saga Medical School, Saga, Japan aut NATIONALLICENCE 700 1- Kohgo Yutaka Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical College, Asahikawa, Japan aut NATIONALLICENCE 700 1- Yoshikawa Toshikazu Department of Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, Kyoto, Japan aut NATIONALLICENCE 700 1- Okanoue Takeshi Hepatology Center, Saiseikai Suita Hospital, Suita, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/11(2011-11-01), 1300-1306 0944-1174 46:11<1300 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer