caa a22 4500 445889365 CHVBK 20180317145611.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00535-011-0447-1 doi (NATIONALLICENCE)springer-10.1007/s00535-011-0447-1 Effect of lansoprazole versus roxatidine on prevention of bleeding and promotion of ulcer healing after endoscopic submucosal dissection for superficial gastric neoplasia [Elektronische Daten] [Hiroyuki Imaeda, Naoki Hosoe, Hidekazu Suzuki, Yoshimasa Saito, Yosuke Ida, Rieko Nakamura, Yasushi Iwao, Haruhiko Ogata, Toshifumi Hibi] Background: Proton pump inhibitors have been reported to be more useful than histamine-2 receptor antagonists for the prevention of bleeding after endoscopic submucosal dissection (ESD) for superficial gastric neoplasia. The aim of this study was to assess the effects of the proton pump inhibitor lansoprazole and the histamine-2 receptor antagonist roxatidine for the prevention of bleeding and the promotion of ulcer healing after ESD and to compare the cost-effectiveness of these two drugs. Methods: The study subjects were 129 patients who underwent ESD for superficial gastric neoplasia. The patients were randomly assigned to the lansoprazole group (L group) or the roxatidine group (R group). Either drug was administered intravenously from the morning of the ESD day to the day after the ESD, followed by oral treatment for an additional 8weeks. A second-look endoscopy was performed on the day after the ESD, and a repeat endoscopy was performed at 8weeks after the ESD. The incidence of bleeding and the ulcer-healing rate at 8weeks after the ESD were analyzed, as well as the total cost of treatment with these antisecretory agents. Results: Three patients in each group were excluded from the analysis, leaving 62 patients in L group and 61 in R group. Two of the 62 patients (3.2%) in L group and three of the 61 patients (4.9%) in R group showed bleeding after ESD ; there was no significant difference between the two groups (P=0.68). The ulcer-healing rate was 93.5% (58/62) in L group and 93.4% (57/61) in R group (P=1). The total cost of treatment with the antisecretory agent from the day of the ESD to day 56 after the ESD was Yen 13,212 for lansoprazole and Yen 5,841 for roxatidine. Conclusions: Roxatidine appears to have high cost-effectiveness in the prevention of bleeding and in the promotion of ulcer healing after ESD for superficial gastric neoplasia. Springer, 2011 Bleeding nationallicence Ulcer healing nationallicence Endoscopic submucosal dissection nationallicence Gastric neoplasia nationallicence Roxatidine nationallicence Lansoprazole nationallicence H2-receptor antagonist nationallicence Proton pump inhibitor nationallicence Imaeda Hiroyuki Department of General Internal Medicine, Saitama Medical University, 38 Morohongo, Moroyama-machi, Iruma-gun, 350-0495, Saitama, Japan aut Hosoe Naoki Center for Diagnostic and Therapeutic Endoscopy, School of Medicine, Keio University, Tokyo, Japan aut Suzuki Hidekazu Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut Saito Yoshimasa Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut Ida Yosuke Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut Nakamura Rieko Center for Diagnostic and Therapeutic Endoscopy, School of Medicine, Keio University, Tokyo, Japan aut Iwao Yasushi Center for Diagnostic and Therapeutic Endoscopy, School of Medicine, Keio University, Tokyo, Japan aut Ogata Haruhiko Center for Diagnostic and Therapeutic Endoscopy, School of Medicine, Keio University, Tokyo, Japan aut Hibi Toshifumi Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut Journal of Gastroenterology Springer Japan 46/11(2011-11-01), 1267-1272 0944-1174 46:11<1267 2011 46 535 https://doi.org/10.1007/s00535-011-0447-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00535-011-0447-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Imaeda Hiroyuki Department of General Internal Medicine, Saitama Medical University, 38 Morohongo, Moroyama-machi, Iruma-gun, 350-0495, Saitama, Japan aut NATIONALLICENCE 700 1- Hosoe Naoki Center for Diagnostic and Therapeutic Endoscopy, School of Medicine, Keio University, Tokyo, Japan aut NATIONALLICENCE 700 1- Suzuki Hidekazu Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut NATIONALLICENCE 700 1- Saito Yoshimasa Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut NATIONALLICENCE 700 1- Ida Yosuke Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut NATIONALLICENCE 700 1- Nakamura Rieko Center for Diagnostic and Therapeutic Endoscopy, School of Medicine, Keio University, Tokyo, Japan aut NATIONALLICENCE 700 1- Iwao Yasushi Center for Diagnostic and Therapeutic Endoscopy, School of Medicine, Keio University, Tokyo, Japan aut NATIONALLICENCE 700 1- Ogata Haruhiko Center for Diagnostic and Therapeutic Endoscopy, School of Medicine, Keio University, Tokyo, Japan aut NATIONALLICENCE 700 1- Hibi Toshifumi Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan aut NATIONALLICENCE 773 0- Journal of Gastroenterology Springer Japan 46/11(2011-11-01), 1267-1272 0944-1174 46:11<1267 2011 46 535 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer