caa a22 4500 463157761 CHVBK 20180406164739.0 cr unu---uuuuu 170326e20070201xx s 000 0 eng 10.1007/s10286-006-0395-7 doi (NATIONALLICENCE)springer-10.1007/s10286-006-0395-7 The autonomic nervous system at high altitude [Elektronische Daten] [Roger Hainsworth, Mark Drinkhill, Maria Rivera-Chira] The effects of hypobaric hypoxia in visitors depend not only on the actual elevation but also on the rate of ascent. Sympathetic activity increases and there are increases in blood pressure and heart rate. Pulmonary vasoconstriction leads to pulmonary hypertension, particularly during exercise. The sympathetic excitation results from hypoxia, partly through chemoreceptor reflexes and partly through altered baroreceptor function. High pulmonary arterial pressures may also cause reflex systemic vasoconstriction. Most permanent high altitude dwellers show excellent adaptation although there are differences between populations in the extent of the ventilatory drive and the erythropoiesis. Some altitude dwellers, particularly Andeans, may develop chronic mountain sickness, the most prominent characteristic of which being excessive polycythaemia. Excessive hypoxia due to peripheral chemoreceptor dysfunction has been suggested as a cause. The hyperviscous blood leads to pulmonary hypertension, symptoms of cerebral hypoperfusion, and eventually right heart failure and death. Steinkopff Verlag Darmstadt, 2007 altitude nationallicence mountain sickness nationallicence hypoxia nationallicence polycythemia nationallicence respiration nationallicence chemoreceptors nationallicence baroreceptors nationallicence autonomic nervous system nationallicence Hainsworth Roger Institute for Cardiovascular Research, University of Leeds, LS2 9JT, Leeds, UK aut Drinkhill Mark Institute for Cardiovascular Research, University of Leeds, LS2 9JT, Leeds, UK aut Rivera-Chira Maria Depto. Academico Ciencias, Biologicas y Fisiologicas, UPCH, Lima, Peru aut Clinical Autonomic Research Steinkopff-Verlag; www.steinkopff.springer.de 17/1(2007-02-01), 13-19 0959-9851 17:1<13 2007 17 10286 https://doi.org/10.1007/s10286-006-0395-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10286-006-0395-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hainsworth Roger Institute for Cardiovascular Research, University of Leeds, LS2 9JT, Leeds, UK aut NATIONALLICENCE 700 1- Drinkhill Mark Institute for Cardiovascular Research, University of Leeds, LS2 9JT, Leeds, UK aut NATIONALLICENCE 700 1- Rivera-Chira Maria Depto. Academico Ciencias, Biologicas y Fisiologicas, UPCH, Lima, Peru aut NATIONALLICENCE 773 0- Clinical Autonomic Research Steinkopff-Verlag; www.steinkopff.springer.de 17/1(2007-02-01), 13-19 0959-9851 17:1<13 2007 17 10286 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer