caa a22 4500 463157826 CHVBK 20180406164739.0 cr unu---uuuuu 170326e20070201xx s 000 0 eng 10.1007/s10286-006-0378-8 doi (NATIONALLICENCE)springer-10.1007/s10286-006-0378-8 Altered venous capacitance as a cause of postprandial hypotension in multiple system atrophy [Elektronische Daten] [Motoko Takamori, Masaaki Hirayama, Rei Kobayashi, Hiroki Ito, Naoki Mabuchi, Tomohiko Nakamura, Norio Hori, Yasuo Koike, Gen Sobue] Patients with multiple system atrophy (MSA) often have clinically significant postprandial hypotension (PPH). To elucidate the cause of insufficient cardiac preload augmentation that underlies PPH, we recorded calf venous capacitance (CVC) by strain-gauge plethysmography, in 17 MSA patients and eight healthy controls before and after oral glucose ingestion. Among 17 MSA patients, nine who showed a decrease in systolic blood pressure exceeding 20mmHg and were diagnosed with PPH. MSA patients without PPH showed a significant decrease in CVC and a significant increase in cardiac output after oral glucose ingestion, as did controls; those with MSA exhibiting PPH showed a significant increase in CVC and no significant change in cardiac output. The change in CVC correlated positively with the decrease in systolic and diastolic blood pressure after glucose ingestion, and also correlated negatively with the increase in cardiac output. Physiologically, PPH is prevented by a decrease in venous capacitance, which increases circulating blood volume and cardiac output. In some MSA patients, failure of venous capacitance to decrease may induce PPH. Steinkopff Verlag Darmstadt, 2006 postprandial nationallicence hypotension nationallicence multiple system atrophy nationallicence venous capacitance nationallicence autonomic nervous system nationallicence Takamori Motoko Dept. of Neurology, Nagoya University Graduate School of Medicine, 466-8550, Nagoya, Japan aut Hirayama Masaaki Dept. of Neurology, Nagoya University Graduate School of Medicine, 466-8550, Nagoya, Japan aut Kobayashi Rei Dept. of Neurology, Nagoya Medical Center, Nagoya, Japan aut Ito Hiroki Dept. of Neurology, Nagoya University Graduate School of Medicine, 466-8550, Nagoya, Japan aut Mabuchi Naoki Dept. of Neurology, Okazaki Municipal Hospital, Aichi, Japan aut Nakamura Tomohiko Dept. of Neurology, Nagoya University Graduate School of Medicine, 466-8550, Nagoya, Japan aut Hori Norio Dept. of Neurology, Nagoya University Graduate School of Medicine, 466-8550, Nagoya, Japan aut Koike Yasuo Dept. of Health Science, Nagoya University Graduate School of Medicine, Nagoya, Japan aut Sobue Gen Dept. of Neurology, Nagoya University Graduate School of Medicine, 466-8550, Nagoya, Japan aut Clinical Autonomic Research Steinkopff-Verlag; www.steinkopff.springer.de 17/1(2007-02-01), 20-25 0959-9851 17:1<20 2007 17 10286 https://doi.org/10.1007/s10286-006-0378-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10286-006-0378-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Takamori Motoko Dept. of Neurology, Nagoya University Graduate School of Medicine, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Hirayama Masaaki Dept. of Neurology, Nagoya University Graduate School of Medicine, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Kobayashi Rei Dept. of Neurology, Nagoya Medical Center, Nagoya, Japan aut NATIONALLICENCE 700 1- Ito Hiroki Dept. of Neurology, Nagoya University Graduate School of Medicine, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Mabuchi Naoki Dept. of Neurology, Okazaki Municipal Hospital, Aichi, Japan aut NATIONALLICENCE 700 1- Nakamura Tomohiko Dept. of Neurology, Nagoya University Graduate School of Medicine, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Hori Norio Dept. of Neurology, Nagoya University Graduate School of Medicine, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Koike Yasuo Dept. of Health Science, Nagoya University Graduate School of Medicine, Nagoya, Japan aut NATIONALLICENCE 700 1- Sobue Gen Dept. of Neurology, Nagoya University Graduate School of Medicine, 466-8550, Nagoya, Japan aut NATIONALLICENCE 773 0- Clinical Autonomic Research Steinkopff-Verlag; www.steinkopff.springer.de 17/1(2007-02-01), 20-25 0959-9851 17:1<20 2007 17 10286 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer