caa a22 4500 463157931 CHVBK 20180406164739.0 cr unu---uuuuu 170326e20071201xx s 000 0 eng 10.1007/s10286-007-0441-0 doi (NATIONALLICENCE)springer-10.1007/s10286-007-0441-0 Exercise training improves cardiovascular and autonomic profiles in HIV [Elektronische Daten] [David Spierer, Ronald DeMeersman, Jay Kleinfeld, Eugene McPherson, Robert Fullilove, Augusta Alba, Adrienne Zion] Objectives: Human immunodeficiency virus (HIV) is associated with cardiovascular (CV) and autonomic dysfunction, however the effects of fitness on vascular and autonomic mechanisms in HIV disease are unknown. Methods: We studied forty-eight subjects (40.4± 4.2years) in a cross-sectional design matched for age, gender, BMI, and fitness. Participants were assigned to 1 in 4 groups: 1) Healthy Unfit (HU), 2) Healthy Fit (HF), 3) HIV Positive Unfit (HPU), and 4) HIV Positive Fit (HPF). Fitness was assessed via open-circuit spirometry; arterial compliance and autonomic modulations were measured via applanation tonometry and power spectral analysis, respectively, and baroreflex sensitivity was obtained using the alpha index. Results: Arterial compliance was augmented in HPF vs. HPU [7.4±1.9mmHg × second vs. 4.4±1.7mmHg × second (P=0.006)]. Parasympathetic modulation was higher in HPF vs. HPU [2244.5±2997.6msecond2 vs. 489.1±552.9msecond2 (P<0.05)]. Sympathetic modulation was lower in HPF vs. HU [4.7±5.0mmHg2 vs. 12.9± 9.7mmHg2 (P<0.05)]. Baroreflex sensitivity was higher in HPF vs. HPU [17.3±10.2msecond/mmHg vs. 7.4±3.8msecond/mmHg (P=0.003)], and HPF vs. HU [17.3±10.2msecond/mmHg vs. 6.2±3.0msecond/mmHg (P=0.004)]. Conclusions: Augmentations in arterial compliance and baroreflex sensitivity associated with fitness portent an improved CV and autonomic profile for HIV-positive individuals. Physical activity may be an adjuvant method to enhance the overall vascular health in HIV-compromised individuals. Springer, 2007 immunodeficiency nationallicence HIV nationallicence exercise nationallicence fitness nationallicence baroreflex nationallicence autonomic nervous system nationallicence Spierer David Coler Goldwater Specialty Hospital and Nursing Facility, Roosevelt Island, NY, USA aut DeMeersman Ronald Dept. of Rehabilitation Medicine, College of Physicians & Surgeons, New York, NY, USA aut Kleinfeld Jay Coler Goldwater Specialty Hospital and Nursing Facility, Roosevelt Island, NY, USA aut McPherson Eugene Coler Goldwater Specialty Hospital and Nursing Facility, Roosevelt Island, NY, USA aut Fullilove Robert Mailman School of Public Health, Columbia University, New York, NY, USA aut Alba Augusta Coler Goldwater Specialty Hospital and Nursing Facility, Roosevelt Island, NY, USA aut Zion Adrienne Teachers College, Columbia University, New York, NY, USA aut https://doi.org/10.1007/s10286-007-0441-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10286-007-0441-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Spierer David Coler Goldwater Specialty Hospital and Nursing Facility, Roosevelt Island, NY, USA aut NATIONALLICENCE 700 1- DeMeersman Ronald Dept. of Rehabilitation Medicine, College of Physicians & Surgeons, New York, NY, USA aut NATIONALLICENCE 700 1- Kleinfeld Jay Coler Goldwater Specialty Hospital and Nursing Facility, Roosevelt Island, NY, USA aut NATIONALLICENCE 700 1- McPherson Eugene Coler Goldwater Specialty Hospital and Nursing Facility, Roosevelt Island, NY, USA aut NATIONALLICENCE 700 1- Fullilove Robert Mailman School of Public Health, Columbia University, New York, NY, USA aut NATIONALLICENCE 700 1- Alba Augusta Coler Goldwater Specialty Hospital and Nursing Facility, Roosevelt Island, NY, USA aut NATIONALLICENCE 700 1- Zion Adrienne Teachers College, Columbia University, New York, NY, USA aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer