caa a22 4500 463157966 CHVBK 20180406164739.0 cr unu---uuuuu 170326e20071201xx s 000 0 eng 10.1007/s10286-007-0436-x doi (NATIONALLICENCE)springer-10.1007/s10286-007-0436-x Treatment of autonomic neuropathy, postural tachycardia and orthostatic syncope with octreotide LAR [Elektronische Daten] [Robert Hoeldtke, Kimberly Bryner, Martin Hoeldtke, Gerald Hobbs] The purpose of this study was to determine whether autonomic neuropathy and the postural tachycardia syndrome can be treated with octreotide LAR (Long Acting Release). This was an open-label pilot project. Protocol 1 Patients with autonomic neuropathy (n = 4) were given increasing doses of octreotide LAR once a month for three months. Blood pressure was measured in the sitting posture every two weeks. Pretreatment mean blood pressure averaged 83.8 ± 7.1 mm Hg. After four, six and eight weeks of therapy the blood pressures averaged 96.3 ± 6.4, 98.2 ± 6.1 (p < .025), and 104.1 ± 3.1 (p < .025) respectively. Therapy led to a dramatic improvement in symptoms in one patient but another had an unacceptable elevation in supine blood pressure. Protocol 2 Patients with POTS or orthostatic intolerance were given 10, 20, or 30 mg of octreotide LAR over three months. Seven patients entered and five completed the study. After two months treatment, standing time increased from 36.0 ± 9.2 to 59.2 ± .8 minutes (p < .01). Heart rate in the standing position was suppressed from 106 ± .83 to 93.2 ± .8 beats per minute (p < .05). Orthostatic dizziness and chronic fatigue improved. We conclude that octreotide LAR can be used to treat autonomic neuropathy but there is a risk of an excessive pressor response. Octreotide LAR improved standing time and suppressed tachycardia in patients with orthostatic intolerance. Springer, 2007 postural tachycardia nationallicence octreotide nationallicence midodrine nationallicence autonomic nervous system nationallicence Hoeldtke Robert Dept. of Medicine, West Virginia University, One Medical Center Drive, PO Box 9159, 26506-9159, Morgantown, WV, USA aut Bryner Kimberly Dept. of Medicine, West Virginia University, One Medical Center Drive, PO Box 9159, 26506-9159, Morgantown, WV, USA aut Hoeldtke Martin Dept. of Medicine, West Virginia University, One Medical Center Drive, PO Box 9159, 26506-9159, Morgantown, WV, USA aut Hobbs Gerald Dept. of Community Medicine and Statistics, West Virginia University, Morgantown, WV, USA aut https://doi.org/10.1007/s10286-007-0436-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10286-007-0436-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hoeldtke Robert Dept. of Medicine, West Virginia University, One Medical Center Drive, PO Box 9159, 26506-9159, Morgantown, WV, USA aut NATIONALLICENCE 700 1- Bryner Kimberly Dept. of Medicine, West Virginia University, One Medical Center Drive, PO Box 9159, 26506-9159, Morgantown, WV, USA aut NATIONALLICENCE 700 1- Hoeldtke Martin Dept. of Medicine, West Virginia University, One Medical Center Drive, PO Box 9159, 26506-9159, Morgantown, WV, USA aut NATIONALLICENCE 700 1- Hobbs Gerald Dept. of Community Medicine and Statistics, West Virginia University, Morgantown, WV, USA aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer