caa a22 4500 463158016 CHVBK 20180406164739.0 cr unu---uuuuu 170326e20070601xx s 000 0 eng 10.1007/s10286-007-0411-6 doi (NATIONALLICENCE)springer-10.1007/s10286-007-0411-6 Relationships between heart rate variability, vascular function, and adiposity in children [Elektronische Daten] [Christopher Kaufman, Daniel Kaiser, Julia Steinberger, Donald Dengel] Objective: To examine the relationships and interactions between cardiovascular autonomic nervous system (cANS) function, adiposity, and vascular function in children of varying levels of adiposity. Methods: Participants were children (19M, 17F, age=11.5±0.1years) who had cANS function assessed via heart rate variability (HRV) methods during resting conditions. Vascular function was assessed with brachial artery flow-mediated dilation (FMD) and nitroglycerin-induced dilation. Spectral power of HRV was calculated for high frequency normalized units (HFnu; measure of PSNS activity) and low frequency:high frequency ratio (LF:HF; overall sympathovagal balance). A blood sample was drawn for measurement of fasting insulin, glucose, lipids, and C-reactive protein (CRP). Results were reported as mean±SEM. Results: FMD peak dilation was positively related to HFnu (r=0.48, P=0.01) and negatively related to LF:HF (r=−0.51, P=0.01) indicating that reduced parasympathetic activity and states of dysfunctional sympathovagal balance were associated with decreased vascular function. After adjustment for confounding factors (insulin, CRP, age) and fat mass, the relationships between these measures of cANS and vascular function remained moderately strong and significant. Discussion: These data indicate a relationship between cANS and vascular function that is independent of fat mass, inflammation (CRP), and fasting insulin in children of varying levels of adiposity. These relationships and the mechanisms by which they exist require further study to allow for the identification of appropriate therapies for children with high levels of adiposity given the likelihood of them having concomitant cANS and vascular dysfunction. Springer, 2007 cardiac autonomic function nationallicence flow-mediated dilation nationallicence pediatrics nationallicence cardiovascular disease nationallicence Kaufman Christopher School of Kinesiology, University of Minnesota, Minneapolis, MN, USA aut Kaiser Daniel Dept. of Medicine, University of Minnesota, Minneapolis, MN, USA aut Steinberger Julia Dept. of Pediatrics, University of Minnesota, Minneapolis, MN, USA aut Dengel Donald School of Kinesiology, University of Minnesota, Minneapolis, MN, USA aut https://doi.org/10.1007/s10286-007-0411-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10286-007-0411-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kaufman Christopher School of Kinesiology, University of Minnesota, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Kaiser Daniel Dept. of Medicine, University of Minnesota, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Steinberger Julia Dept. of Pediatrics, University of Minnesota, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Dengel Donald School of Kinesiology, University of Minnesota, Minneapolis, MN, USA aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer