caa a22 4500 463158024 CHVBK 20180406164740.0 cr unu---uuuuu 170326e20070601xx s 000 0 eng 10.1007/s10286-007-0417-0 doi (NATIONALLICENCE)springer-10.1007/s10286-007-0417-0 Effect of dimenhydrinate on autonomic activity in humans [Elektronische Daten] [Jason Carter, Chester Ray] The purpose of this study was to examine the effect of dimenhydrinate on resting muscle sympathetic nerve activity (MSNA), the vestibulosympathetic reflex, and the baroreflexes. Sixteen subjects participated in two double-blinded studies that measured mean arterial pressure (MAP), heart rate (HR), and MSNA responses before and after oral administration of dimenhydrinate (100mg) or a placebo. In study one, 3min of head-down rotation (HDR) was performed to engage the otolith organs. Dimenhydrinate (n=10) did not alter resting MSNA, MAP, or HR. HDR increased MSNA before (Δ5±1 bursts/min; P<0.01) and after (Δ4±1 bursts/min; P<0.01) drug administration, but these responses were not different from the placebo (n=6). In study two, 4min of lower body negative pressure (LBNP) at −30mmHg was performed. During the thirdmin of LBNP, HDR was performed. MSNA increased during the first 2min of LBNP before (Δ13±2 bursts/min; P<0.01) and after (Δ14±2 bursts/min; P<0.01) dimenhydrinate. HDR combined with LBNP increased MSNA further during the thirdmin of LBNP (Δ18±2 bursts/min before and Δ17±2 bursts/min after dimenhydrinate; P<0.01). These responses were not significantly different from the placebo. In contrast, HR responses to LBNP during the dimenhydrinate trial were increased when compared to all other trials (Δ5±1 beats/min; P<0.01). These results indicate that dimenhydrinate augments heart rate responses to baroreceptor unloading, but does not alter resting MSNA, the sympathetic baroreflexes, or the vestibulosympathetic reflex. Springer, 2007 Dramamine nationallicence baroreflex nationallicence vestibulosympathetic reflex nationallicence sympathetic activity nationallicence Carter Jason Dept. of Exercise Science, Health and Physical Education, Michigan Technological University, 1400 Townsend Drive, 49931, Houghton, MI, USA aut Ray Chester Heart and Vascular Institute, Pennsylvania State University College of Medicine, Hershey, PA, USA aut https://doi.org/10.1007/s10286-007-0417-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10286-007-0417-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Carter Jason Dept. of Exercise Science, Health and Physical Education, Michigan Technological University, 1400 Townsend Drive, 49931, Houghton, MI, USA aut NATIONALLICENCE 700 1- Ray Chester Heart and Vascular Institute, Pennsylvania State University College of Medicine, Hershey, PA, USA aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer