caa a22 4500 463158032 CHVBK 20180406164740.0 cr unu---uuuuu 170326e20070601xx s 000 0 eng 10.1007/s10286-007-0419-y doi (NATIONALLICENCE)springer-10.1007/s10286-007-0419-y Jordan Jens Franz Volhard Clinical Research Center, Max Delbrück Center, and HELIOS Klinikum Berlin, Charité Campus Buch, Haus 129, Wiltbergstr. 50, 13125, Berlin, Germany aut Research highlights from the literature [Elektronische Daten] [Jens Jordan] The peptide catestatin is produced from the precursor protein chromogranin A. Apparently, catestatin regulates autonomic nervous system function through blockade of ganglionic nicotinic acetylcholine receptors. A recent study suggests that genetic polymorphisms affecting catestatin may have a bearing on human blood pressure regulation. In a study in autonomic failure patients, inhibition of carbohydrate reabsorption with the alpha glucosidase inhibitor acarbose attenuated postprandial hypotension. The study may be therapeutically relevant. The neuronal norepinephrine transporter affects cardiovascular regulation through combination of central nervous and peripheral mechanisms. In a new study, pharmacological norepinephrine transporter inhibition elicited a profound pressor response in patients with central autonomic failure due to multiple system atrophy. Blood pressure did not respond in patients with peripheral autonomic neuropathies. The investigators suggest that the pressor response results from peripheral norepinephrine transporter inhibition that is unopposed by a central sympatholytic effect. In vitro, human growth hormone has a neuroprotective effect. A small placebo-controlled clinical trial evaluated the safety of human recombinant growth hormone treatment in patients with multiple system atrophy. The intervention was well tolerated. Unfortunately, the study was to small to evaluate efficacy. Springer, 2007 catestatin nationallicence chromogranin A nationallicence blood pressure genetics nationallicence autonomic failure nationallicence postprandial hypotension nationallicence orthostatic hypotension nationallicence norepinephrine transporter nationallicence acarbose nationallicence alpha-glucosidase nationallicence growth hormone nationallicence neuroprotection nationallicence https://doi.org/10.1007/s10286-007-0419-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10286-007-0419-y text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Jordan Jens Franz Volhard Clinical Research Center, Max Delbrück Center, and HELIOS Klinikum Berlin, Charité Campus Buch, Haus 129, Wiltbergstr. 50, 13125, Berlin, Germany aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 458059609 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer