caa a22 4500 463158059 CHVBK 20180406164740.0 cr unu---uuuuu 170326e20070601xx s 000 0 eng 10.1007/s10286-007-0407-2 doi (NATIONALLICENCE)springer-10.1007/s10286-007-0407-2 The effects of lorazepam on skin conductance responses to aversive stimuli in healthy subjects [Elektronische Daten] [Martin Siepmann, Benjamin Heine, Andreas Kluge, Tjalf Ziemssen, Michael Mück-Weymann, Wilhelm Kirch] Background: Autonomic responses to aversive stimuli are widely used to model anxiolytic drug effects in healthy humans. Benzodiazepine anxiolytics dose dependently attenuate autonomic responses to aversive stimuli by their anxiolytic as well as sedative action. The present study aimed to examine the effects of non-sedative doses of lorazepam on skin cutaneous responses to aversive stimuli and subjective mood. Methods: A randomized, double blind, cross over study of 12 healthy male volunteers aged 24years (23-32; median; range) was carried out. Subjects received single oral doses of 0.5 and 1.0mg lorazepam as well as placebo on three different occasions with at least 5days in-between. Skin conductance responses (SCRs) to unpleasant pictures and noises, pupillary unrest index as well as subjective levels of anxiety were measured repeatedly before and after drug administration. Results: SCRs were found significantly lower 2hours following ingestion of 0.5mg lorazepam as well as 1, 2 and 3hours after 1.0mg lorazepam were given as compared to baseline conditions. By contrast, administration of placebo did not influence SCRs to a significant extent. Both doses of lorazepam did not change pupillary unrest index nor subjective mood. Conclusions: Lorazepam may attenuate SCRs to aversive stimuli without affecting vigilance nor subjective mood. Attenuation of autonomic responses to aversive stimuli may not be specific for an anxiolytic effect. Springer, 2007 skin-conductance responses nationallicence lorazepam nationallicence anxiolytic nationallicence sedative nationallicence subjective mood nationallicence healthy subjects nationallicence Siepmann Martin Institute of Clinical Pharmacology, Medical Faculty, Technical University, Fiedlerstraße 27, 01307, Dresden, Germany aut Heine Benjamin Institute of Clinical Pharmacology, Medical Faculty, Technical University, Fiedlerstraße 27, 01307, Dresden, Germany aut Kluge Andreas Institute of Clinical Pharmacology, Medical Faculty, Technical University, Fiedlerstraße 27, 01307, Dresden, Germany aut Ziemssen Tjalf Autonomic Laboratory, Department of Neurology, Medical Faculty, Technical University, Dresden, Germany aut Mück-Weymann Michael Clinic for Psychotherapy and Psychosomatic Medicine, Medical Faculty, Technical University, Dresden, Germany aut Kirch Wilhelm Institute of Clinical Pharmacology, Medical Faculty, Technical University, Fiedlerstraße 27, 01307, Dresden, Germany aut https://doi.org/10.1007/s10286-007-0407-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10286-007-0407-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Siepmann Martin Institute of Clinical Pharmacology, Medical Faculty, Technical University, Fiedlerstraße 27, 01307, Dresden, Germany aut NATIONALLICENCE 700 1- Heine Benjamin Institute of Clinical Pharmacology, Medical Faculty, Technical University, Fiedlerstraße 27, 01307, Dresden, Germany aut NATIONALLICENCE 700 1- Kluge Andreas Institute of Clinical Pharmacology, Medical Faculty, Technical University, Fiedlerstraße 27, 01307, Dresden, Germany aut NATIONALLICENCE 700 1- Ziemssen Tjalf Autonomic Laboratory, Department of Neurology, Medical Faculty, Technical University, Dresden, Germany aut NATIONALLICENCE 700 1- Mück-Weymann Michael Clinic for Psychotherapy and Psychosomatic Medicine, Medical Faculty, Technical University, Dresden, Germany aut NATIONALLICENCE 700 1- Kirch Wilhelm Institute of Clinical Pharmacology, Medical Faculty, Technical University, Fiedlerstraße 27, 01307, Dresden, Germany aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer