caa a22 4500 463158164 CHVBK 20180406164740.0 cr unu---uuuuu 170326e20070601xx s 000 0 eng 10.1007/s10286-007-0422-3 doi (NATIONALLICENCE)springer-10.1007/s10286-007-0422-3 Khurana Ramesh The Union Memorial Hospital, 201 East University Parkway, Room 411, 33rd Street Building, 21218, Baltimore, MD, USA aut Cold face test: adrenergic phase [Elektronische Daten] [Ramesh Khurana] The cold face test (CFT) evokes reflex bradycardia and pressor responses. Bradycardia has been used to assess vagal function. This study evaluated two aspects of physiology and clinical applicability of the pressor response. During constant monitoring of blood pressure (Finapres) and heart rate (EKG), CFT was induced by the application of three cold packs (0.5°C) to the face for 1min. Group 1: Latencies of systolic blood pressure (SBP) and heart rate (HR) response to the CFT were recorded in 10 normal subjects. Group 2: CFT was performed in eight normal subjects after cholinergic blockade with atropine (0.03mg/kg body weight intravenously). Group 3: Four patients with baroreflex failure and five patients with pure autonomic failure were subjected to CFT. In Group 1, mean latency of CFT-induced SBP rise (mean±SD) (13.8±16.6s) was longer than that of bradycardia (5.6±4.6s). In Group 2, bradycardia was abolished in all subjects and SBP was unaffected after atropine administration. In Group 3, patients with baroreflex failure demonstrated normal HR and SBP responses to CFT. In the pure autonomic failure patients, bradycardia was absent and SBP response was either absent or subnormal. The adrenergic phase of the CFT is independent of the cholinergic phase (bradycardia) and baroreceptors. Rise in SBP is useful in evaluating the integrity of the efferent sympathetic pathway with baroreflex failure. Absence of SBP rise in response to the CFT may be of diagnostic value in detecting the sympathetic component of pure autonomic failure. Springer, 2007 atropine nationallicence adrenergic phase nationallicence baroreflex failure nationallicence pure autonomic failure nationallicence https://doi.org/10.1007/s10286-007-0422-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10286-007-0422-3 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Khurana Ramesh The Union Memorial Hospital, 201 East University Parkway, Room 411, 33rd Street Building, 21218, Baltimore, MD, USA aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer