caa a22 4500 463158202 CHVBK 20180406164740.0 cr unu---uuuuu 170326e20070401xx s 000 0 eng 10.1007/s10286-007-0410-7 doi (NATIONALLICENCE)springer-10.1007/s10286-007-0410-7 Autonomic and Cognitive dysfunction in Parkinson's disease [Elektronische Daten] [Juan Idiaquez, Eduardo Benarroch, Hugo Rosales, Pablo Milla, Lily Ríos] Objective: To investigate whether there is an association between autonomic failure and cognitive impairment in patients with idiopathic Parkinson's disease (PD) Methods: 40 PD patients and 30 age matched controls were assessed for cognitive and behavioral manifestations using the Mini-Mental State Examination (MMSE), the Frontal Assessment Battery (FAB), the Blessed scale and Cornell scale for depression. The subjects were also assessed for orthostatic hypotension (OH), postprandial hypotension (PPH), heart rate responses to deep breathing (HRDB) and autonomic symptoms using the Scale for Outcomes in PD for autonomic symptoms (SCOPA AUT). Results: There was a correlation between the severity of motor symptoms and cognitive impairment in our PD patients. Eleven of the 40 PD patients fulfilled the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria of dementia. The presence of OH or PPH did not correlate with the severity of cognitive impairment in our PD cases. However, PD patients with dementia reported more cardiovascular symptoms than PD patients without dementia. There was no correlation between gastrointestinal or urologic symptoms and cognitive impairment in our PD cases. Conclusion: The results of this limited study indicate that despite the higher incidence of cardiovascular symptoms in PD patients with dementia than in those without dementia, there is no consistent association between OH or PPH and cognitive deficits in PD. The lack of correlation between OH, gastrointestinal and urinary symptoms with cognitive impairment suggests that cognitive and autonomic involvement progresses independently from each other and variably among PD patients. Steinkopff Verlag Darmstadt, 2007 dementia nationallicence Parkinson disease nationallicence autonomic nationallicence orthostatic hypotension nationallicence autonomic nervous system nationallicence Idiaquez Juan Universidad de Valparaíso, Valparaíso, Chile aut Benarroch Eduardo Mayo Clinic, Rochester, MN, USA aut Rosales Hugo Universidad de Valparaíso, Valparaíso, Chile aut Milla Pablo Universidad de Valparaíso, Valparaíso, Chile aut Ríos Lily Universidad de Valparaíso, Valparaíso, Chile aut Clinical Autonomic Research Steinkopff-Verlag; www.steinkopff.springer.de 17/2(2007-04-01), 93-98 0959-9851 17:2<93 2007 17 10286 https://doi.org/10.1007/s10286-007-0410-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10286-007-0410-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Idiaquez Juan Universidad de Valparaíso, Valparaíso, Chile aut NATIONALLICENCE 700 1- Benarroch Eduardo Mayo Clinic, Rochester, MN, USA aut NATIONALLICENCE 700 1- Rosales Hugo Universidad de Valparaíso, Valparaíso, Chile aut NATIONALLICENCE 700 1- Milla Pablo Universidad de Valparaíso, Valparaíso, Chile aut NATIONALLICENCE 700 1- Ríos Lily Universidad de Valparaíso, Valparaíso, Chile aut NATIONALLICENCE 773 0- Clinical Autonomic Research Steinkopff-Verlag; www.steinkopff.springer.de 17/2(2007-04-01), 93-98 0959-9851 17:2<93 2007 17 10286 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer