caa a22 4500 463158261 CHVBK 20180406164740.0 cr unu---uuuuu 170326e20070401xx s 000 0 eng 10.1007/s10286-007-0396-1 doi (NATIONALLICENCE)springer-10.1007/s10286-007-0396-1 Cardiac sympathetic denervation preceding motor signs in Parkinson disease [Elektronische Daten] [David Goldstein, Yehonatan Sharabi, Barbara Karp, Oladi Bentho, Ahmed Saleem, Karel Pacak, Graeme Eisenhofer] There is substantial interest in identifying biomarkers to detect early Parkinson disease (PD). Cardiac noradrenergic denervation and attenuated baroreflex-cardiovagal function occur in de novo PD, but whether these abnormalities can precede PD has been unknown. Here we report the case of a patient who had profoundly decreased left ventricular myocardial 6-[18F]fluorodopamine-derived radioactivity and low baroreflex-cardiovagal gain, 4years before the onset of symptoms and signs of PD. The results lead us to hypothesize that cardiac noradrenergic denervation and decreased baroreflex-cardiovagal function may occur early in the pathogenesis of PD. Steinkopff Verlag Darmstadt, 2007 Parkinson disease nationallicence sympathetic nervous system nationallicence baroreflex nationallicence heart nationallicence imaging techniques nationallicence autonomic nervous system nationallicence Goldstein David Clinical Neurocardiology Section, NINDS, NIH, 10 Center Drive MSC-1620, Building 10 Room 6N252, 20892-1620, Bethesda, MD, USA aut Sharabi Yehonatan Clinical Neurocardiology Section, NINDS, NIH, 10 Center Drive MSC-1620, Building 10 Room 6N252, 20892-1620, Bethesda, MD, USA aut Karp Barbara Clinical Neurosciences Program, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA aut Bentho Oladi Clinical Neurocardiology Section, NINDS, NIH, 10 Center Drive MSC-1620, Building 10 Room 6N252, 20892-1620, Bethesda, MD, USA aut Saleem Ahmed Clinical Neurocardiology Section, NINDS, NIH, 10 Center Drive MSC-1620, Building 10 Room 6N252, 20892-1620, Bethesda, MD, USA aut Pacak Karel Reproductive Biology and Medicine Branch, National Institute of Child Health and Development, NIH, Bethesda, MD, USA aut Eisenhofer Graeme Clinical Neurocardiology Section, NINDS, NIH, 10 Center Drive MSC-1620, Building 10 Room 6N252, 20892-1620, Bethesda, MD, USA aut Clinical Autonomic Research Steinkopff-Verlag; www.steinkopff.springer.de 17/2(2007-04-01), 118-121 0959-9851 17:2<118 2007 17 10286 https://doi.org/10.1007/s10286-007-0396-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10286-007-0396-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Goldstein David Clinical Neurocardiology Section, NINDS, NIH, 10 Center Drive MSC-1620, Building 10 Room 6N252, 20892-1620, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Sharabi Yehonatan Clinical Neurocardiology Section, NINDS, NIH, 10 Center Drive MSC-1620, Building 10 Room 6N252, 20892-1620, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Karp Barbara Clinical Neurosciences Program, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Bentho Oladi Clinical Neurocardiology Section, NINDS, NIH, 10 Center Drive MSC-1620, Building 10 Room 6N252, 20892-1620, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Saleem Ahmed Clinical Neurocardiology Section, NINDS, NIH, 10 Center Drive MSC-1620, Building 10 Room 6N252, 20892-1620, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Pacak Karel Reproductive Biology and Medicine Branch, National Institute of Child Health and Development, NIH, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Eisenhofer Graeme Clinical Neurocardiology Section, NINDS, NIH, 10 Center Drive MSC-1620, Building 10 Room 6N252, 20892-1620, Bethesda, MD, USA aut NATIONALLICENCE 773 0- Clinical Autonomic Research Steinkopff-Verlag; www.steinkopff.springer.de 17/2(2007-04-01), 118-121 0959-9851 17:2<118 2007 17 10286 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer