caa a22 4500 463158296 CHVBK 20180406164740.0 cr unu---uuuuu 170326e20070401xx s 000 0 eng 10.1007/s10286-006-0393-9 doi (NATIONALLICENCE)springer-10.1007/s10286-006-0393-9 Cutaneous postural vasoconstriction is modified by exogenous but not endogenous female hormones in young women [Elektronische Daten] [Gemma Bishop, Margaret Brown] Previously reported attenuation of skin postural vasoconstriction in women during the luteal menstrual cycle phase may be due to a progesterone-mediated decrease in myogenic or veno-arteriolar (VAR) mechanisms. Skin perfusion was measured in the shin and foot dorsum by Laser Doppler Fluxometry during leg dependency that increased vascular transmural pressure below (myogenic constriction only) and above (myogenic and VAR) the 25mmHg threshold for activation of the VAR, and during venous distension to activate the VAR alone (cuff inflation to 50mmHg). In six young women with normal menstrual cycles, vasoconstrictor responses to all interventions did not differ between days 7-13 (follicular) and 18-23 (luteal) of the normal menstrual cycle when progesterone levels were low and at their peak respectively. In eight women taking combined oral contraceptives (OC) and tested during pill consumption days, reductions in foot skin perfusion were smaller (P=0.05) than in the luteal phase of the normal cycle for leg dependency below (−36.9±5.2% OC vs. −52.5±7.8% luteal, mean±S.E.M.) and above (−43.7±3.4% OC vs. −55.1±4.8% luteal) the VAR threshold, and for venous distension (−53.1±2.6% OC vs. 66.4±5.5% luteal). In women with normal menstrual cycles, impaired postural vasoconstriction may be confined to those who experience pre-menstrual symptoms rather than a direct effect of endogenous hormones. Reduced vasoconstriction in the dependent foot during OC use is consistent with the known vasodilator action of exogenous hormones and its long-term effects Steinkopff Verlag Darmstadt, 2007 limb dependency nationallicence veno-arteriolar response nationallicence myogenic nationallicence menstrual cycle nationallicence oral contraceptive nationallicence autonomic nervous system nationallicence Bishop Gemma School of Sport and Exercise Sciences, University of Birmingham, B15 2TT, Birmingham, UK aut Brown Margaret School of Sport and Exercise Sciences, University of Birmingham, B15 2TT, Birmingham, UK aut Clinical Autonomic Research Steinkopff-Verlag; www.steinkopff.springer.de 17/2(2007-04-01), 85-92 0959-9851 17:2<85 2007 17 10286 https://doi.org/10.1007/s10286-006-0393-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10286-006-0393-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bishop Gemma School of Sport and Exercise Sciences, University of Birmingham, B15 2TT, Birmingham, UK aut NATIONALLICENCE 700 1- Brown Margaret School of Sport and Exercise Sciences, University of Birmingham, B15 2TT, Birmingham, UK aut NATIONALLICENCE 773 0- Clinical Autonomic Research Steinkopff-Verlag; www.steinkopff.springer.de 17/2(2007-04-01), 85-92 0959-9851 17:2<85 2007 17 10286 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer