caa a22 4500 463158318 CHVBK 20180406164740.0 cr unu---uuuuu 170326e20070401xx s 000 0 eng 10.1007/s10286-007-0409-0 doi (NATIONALLICENCE)springer-10.1007/s10286-007-0409-0 Increased hydration alone does not improve orthostatic tolerance in patients with neurocardiogenic syncope [Elektronische Daten] [Elisabeth Bellard, Jacques-Olivier Fortrat, Marc-Antoine Custaud, Jacques Victor, John Greenleaf, Georges Lefthériotis] In patients with neurocardiogenic syncope, the beneficial effects of increased daily fluid intake, without an accompanying high dose of salt, are unknown. Our aim was to (1) determine whether plasma volume was low in patients with recurrent neurocardiogenic syncope, and (2) determine how recommendation about increased daily fluid intake, without an accompanying high dose of sodium, effects plasma volume and if this potential therapy improves orthostatic tolerance. Eighty-six patients with neurocardiogenic syncope were recruited in a prospective randomized open study. After an initial head-up tilt test, patients were randomly assigned to either the hydration supplementation group (1500 ml of water + 1500mg of NaCl/day) or the no treatment (control) group. After ten days a second head-up tilt test was performed. Plasma volume, osmolality, and total body water were measured at baseline, and heart rate, arterial blood pressure, and cardiac transthoracic impedance were monitored during tilting. Hydration treatment did not affect the number of positive tilt tests (52% initial day, 54% after treatment, NS). In both groups, the overall number of positive tilt tests decreased between the initial and final head-up tilt test. There was no association between low plasma volume and positive tilt test. Patients with the lowest plasma volume were equally distributed in both positive and negative tilt response groups. An increased daily intake of fluid, without an accompanying high dose of salt, had no measurable beneficial effect on tolerance to head-up tilting in patients with neurocardiogenic syncope. Moreover in this patient group there was no association between a low plasma volume and a reduced tolerance to orthostatic stress. Steinkopff Verlag Darmstadt, 2007 autonomic nervous system nationallicence blood volume nationallicence neurally mediated syncope nationallicence Water nationallicence water consumption nationallicence tilt-table test nationallicence Bellard Elisabeth Laboratoire de Physiology, UMR CNRS 6214 Inserm 771, Faculté de Médecine d'Angers rue Haute de Reculée, 49035, Angers, France aut Fortrat Jacques-Olivier Laboratoire de Physiology, UMR CNRS 6214 Inserm 771, Faculté de Médecine d'Angers rue Haute de Reculée, 49035, Angers, France aut Custaud Marc-Antoine Laboratoire de Physiology, UMR CNRS 6214 Inserm 771, Faculté de Médecine d'Angers rue Haute de Reculée, 49035, Angers, France aut Victor Jacques Service de Cardiologie, Centre Hospitalier Universitaire d'Angers, Angers Cedex, France aut Greenleaf John Laboratoire de Physiology, UMR CNRS 6214 Inserm 771, Faculté de Médecine d'Angers rue Haute de Reculée, 49035, Angers, France aut Lefthériotis Georges Laboratoire de Physiology, UMR CNRS 6214 Inserm 771, Faculté de Médecine d'Angers rue Haute de Reculée, 49035, Angers, France aut Clinical Autonomic Research Steinkopff-Verlag; www.steinkopff.springer.de 17/2(2007-04-01), 99-105 0959-9851 17:2<99 2007 17 10286 https://doi.org/10.1007/s10286-007-0409-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10286-007-0409-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bellard Elisabeth Laboratoire de Physiology, UMR CNRS 6214 Inserm 771, Faculté de Médecine d'Angers rue Haute de Reculée, 49035, Angers, France aut NATIONALLICENCE 700 1- Fortrat Jacques-Olivier Laboratoire de Physiology, UMR CNRS 6214 Inserm 771, Faculté de Médecine d'Angers rue Haute de Reculée, 49035, Angers, France aut NATIONALLICENCE 700 1- Custaud Marc-Antoine Laboratoire de Physiology, UMR CNRS 6214 Inserm 771, Faculté de Médecine d'Angers rue Haute de Reculée, 49035, Angers, France aut NATIONALLICENCE 700 1- Victor Jacques Service de Cardiologie, Centre Hospitalier Universitaire d'Angers, Angers Cedex, France aut NATIONALLICENCE 700 1- Greenleaf John Laboratoire de Physiology, UMR CNRS 6214 Inserm 771, Faculté de Médecine d'Angers rue Haute de Reculée, 49035, Angers, France aut NATIONALLICENCE 700 1- Lefthériotis Georges Laboratoire de Physiology, UMR CNRS 6214 Inserm 771, Faculté de Médecine d'Angers rue Haute de Reculée, 49035, Angers, France aut NATIONALLICENCE 773 0- Clinical Autonomic Research Steinkopff-Verlag; www.steinkopff.springer.de 17/2(2007-04-01), 99-105 0959-9851 17:2<99 2007 17 10286 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer