caa a22 4500 463175824 CHVBK 20180406164825.0 cr unu---uuuuu 170326e20071201xx s 000 0 eng 10.1007/s10336-007-0197-2 doi (NATIONALLICENCE)springer-10.1007/s10336-007-0197-2 Acute phase responses of passerine birds: characterization and seasonal variation [Elektronische Daten] [Noah Owen-Ashley, John Wingfield] The acute phase response (APR) is the first line of defense that many vertebrates employ during a pathogenic challenge. This response is composed of a suite of physiological, behavioral, hormonal, and metabolic changes that include fever, iron sequestration, anorexia, adipsia, somnolence, and activation of the hypothalamo-pituitary-adrenal (HPA) axis and suppression of the hypothalamo-pituitary-gonadal (HPG) axis. Although well-studied in mammals and domesticated birds, the APR of passerines is virtually unexplored. Here, we characterize the APR in several species of Emberizidae and examine seasonal variation. Captive and free-living sparrows were treated with lipopolysaccharide (LPS), an immunogenic agent that triggers the APR without actually causing infection. LPS treatment activates the HPA axis, suppresses the HPG axis, decreases activity and food and water intake, and induces short-term hypothermia in captives, as well as inhibiting territorial aggressive behavior and song in free-living males. The magnitude of the APR also varies seasonally in males, implicating a tradeoff between physiological processes within particular life-history stages, such as reproduction. The proximate mechanisms underlying this seasonal modulation may include hormonal suppression by the steroid testosterone and seasonal differences in energy stores, which are rapidly depleted to a minimum body mass threshold as a result of APR-induced sickness behavior. We conclude by comparing this variation in APR to seasonal variation of avian stress responses. Dt. Ornithologen-Gesellschaft e.V., 2007 Acute phase response nationallicence Immune-endocrine interaction nationallicence Sickness behavior nationallicence APP : Acute phase protein nationallicence APR : Acute phase response nationallicence cMGF : Chicken myelomonocytic growth factor nationallicence HPA : Hypothalamo-pituitary-adrenal nationallicence HPG : Hypothalamo-pituitary-gonadal nationallicence HPGH : Hypothalamo-pituitary-growth hormone nationallicence HPT : Hypothalamo-pituitary-thryoid nationallicence IFNγ : Interferon-gamma nationallicence IL-1β : Interleukin-1-beta nationallicence IL-6 : Interleukin-6 nationallicence IL-17 : Interleukin-17 nationallicence LPS : Lipopolysaccharide nationallicence TGFβ : Transforming growth factor-beta nationallicence TNFα : Tumor necrosis factor-alpha nationallicence Owen-Ashley Noah Department of Biology, University of Washington, Box 351800, 98195-1800, Seattle, WA, USA aut Wingfield John Department of Biology, University of Washington, Box 351800, 98195-1800, Seattle, WA, USA aut Journal of Ornithology Springer-Verlag 148(2007-12-01), 583-591 0021-8375 148<583 2007 148 10336 https://doi.org/10.1007/s10336-007-0197-2 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10336-007-0197-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Owen-Ashley Noah Department of Biology, University of Washington, Box 351800, 98195-1800, Seattle, WA, USA aut NATIONALLICENCE 700 1- Wingfield John Department of Biology, University of Washington, Box 351800, 98195-1800, Seattle, WA, USA aut NATIONALLICENCE 773 0- Journal of Ornithology Springer-Verlag 148(2007-12-01), 583-591 0021-8375 148<583 2007 148 10336 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer