caa a22 4500 463178971 CHVBK 20180406164833.0 cr unu---uuuuu 170326e20070101xx s 000 0 eng 10.1007/s00381-006-0175-7 doi (NATIONALLICENCE)springer-10.1007/s00381-006-0175-7 Bone mineral density in survivors of childhood brain tumours [Elektronische Daten] [M. Petraroli, E. D'Alessio, E. Ausili, A. Barini, P. Caradonna, R. Riccardi, M. Caldarelli, A. Rossodivita] Background: Osteopenia has been reported in children surviving acute lymphoblastic leukaemia, apparently as consequence of therapy. Few studies have been published on bone mineral density (BMD) evaluation in children surviving from brain tumours. The endocrine system in these patients is frequently affected as consequence of therapeutic interventions such as cranial irradiation and anti-neoplastic agents: growth hormone deficiency is the most common adverse sequel. The pathogenesis of osteopenia in brain cancer survivors is multi-factorial but still uncertain. Objective: The aim of this study is to examine bone mass in 12 brain cancer survivors and its relationship with their hormonal status. Results and discussion: We observed that most of the patients had a BMD that was lower than normal in both the lumbar column and in the femoral neck. Bone mass loss was higher in the lumbar region rather than in the femoral neck, due to spinal radiation therapy and to the effect of hormonal deficiencies. Particularly hypogonadism, but also multiple hormonal deficiencies, are associated with lower BMD values. Experience in clinical care of these patients suggests the importance of periodic evaluations of BMD, especially in those with secondary hormone deficiencies. Moreover, the periodic assessment of the hypothalamus-pituitary function is essential for an early diagnosis of hormonal insufficiency, primarily hypogonadism, to precociously detect bone mineral loss and to prevent pathological fractures, thus improving the quality of life. Springer-Verlag, 2006 Brain cancer nationallicence Bone density nationallicence Growth Hormone nationallicence Childhood nationallicence Osteoporosis nationallicence Hypogonadism nationallicence Petraroli M. Department of Paediatrics, Università Cattolica del Sacro Cuore (UCSC), Rome, Italy aut D'Alessio E. Department of Paediatrics, Università Cattolica del Sacro Cuore (UCSC), Rome, Italy aut Ausili E. Department of Paediatrics, Università Cattolica del Sacro Cuore (UCSC), Rome, Italy aut Barini A. Department of Clinical Biochemistry, Università Cattolica del Sacro Cuore (UCSC), Rome, Italy aut Caradonna P. Department of Internal Medicine, Università Cattolica del Sacro Cuore (UCSC), Rome, Italy aut Riccardi R. Department of Paediatrics, Università Cattolica del Sacro Cuore (UCSC), Rome, Italy aut Caldarelli M. Section of Paediatric Neurosurgery, Department of Paediatrics, Università Cattolica del Sacro Cuore (UCSC), Rome, Italy aut Rossodivita A. Department of Paediatrics, Università Cattolica del Sacro Cuore (UCSC), Rome, Italy aut Child's Nervous System Springer-Verlag 23/1(2007-01-01), 59-65 0256-7040 23:1<59 2007 23 381 https://doi.org/10.1007/s00381-006-0175-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00381-006-0175-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Petraroli M. Department of Paediatrics, Università Cattolica del Sacro Cuore (UCSC), Rome, Italy aut NATIONALLICENCE 700 1- D'Alessio E. Department of Paediatrics, Università Cattolica del Sacro Cuore (UCSC), Rome, Italy aut NATIONALLICENCE 700 1- Ausili E. Department of Paediatrics, Università Cattolica del Sacro Cuore (UCSC), Rome, Italy aut NATIONALLICENCE 700 1- Barini A. Department of Clinical Biochemistry, Università Cattolica del Sacro Cuore (UCSC), Rome, Italy aut NATIONALLICENCE 700 1- Caradonna P. Department of Internal Medicine, Università Cattolica del Sacro Cuore (UCSC), Rome, Italy aut NATIONALLICENCE 700 1- Riccardi R. Department of Paediatrics, Università Cattolica del Sacro Cuore (UCSC), Rome, Italy aut NATIONALLICENCE 700 1- Caldarelli M. Section of Paediatric Neurosurgery, Department of Paediatrics, Università Cattolica del Sacro Cuore (UCSC), Rome, Italy aut NATIONALLICENCE 700 1- Rossodivita A. Department of Paediatrics, Università Cattolica del Sacro Cuore (UCSC), Rome, Italy aut NATIONALLICENCE 773 0- Child's Nervous System Springer-Verlag 23/1(2007-01-01), 59-65 0256-7040 23:1<59 2007 23 381 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer