caa a22 4500 463178998 CHVBK 20180406164833.0 cr unu---uuuuu 170326e20070101xx s 000 0 eng 10.1007/s00381-006-0172-x doi (NATIONALLICENCE)springer-10.1007/s00381-006-0172-x Multifocal Langerhans cell histiocytosis of the pediatric spine: a case report and literature review [Elektronische Daten] [S. Vadivelu, F. Mangano, C. Miller, J. Leonard] Case report: An 11-month-old boy presented with a 3-month history of lower extremity weakness. CT and MRI of the spine revealed an enhancing epidural mass, extending from T1 through T5 and exiting through multiple foramina. The largest extraspinal extent was located at the T3 vertebral level and was accompanied by complete T3 vertebral collapse. A second lytic lesion at the L2 vertebral body without an obvious enhancing mass was also noted. Open biopsy and decompression of the spinal cord were performed, and histopathological analysis revealed a mixed inflammatory lesion with abundant S-100 and CD1a immunoreactive Langerhans cells consistent with the diagnosis of Langerhans cell histiocytosis (LCH). Discussion: The authors present a very rare pediatric case of spinal LCH causing spinal cord compression. Possible clues to early detection, consideration of differential diagnoses, and a brief literature review are presented. Springer-Verlag, 2006 Langerhans cell histiocytosis nationallicence Histiocytosis X nationallicence Multifocal spinal disease nationallicence Myelopathy nationallicence Spinal tumor nationallicence Vertebra plana nationallicence Vadivelu S. Department of Neurosurgery, St. Louis Children's Hospital, Washington University in St. Louis, One Children Place, Suite 4S20, 63110, St. Louis, MO, USA aut Mangano F. Department of Neurosurgery, St. Louis Children's Hospital, Washington University in St. Louis, One Children Place, Suite 4S20, 63110, St. Louis, MO, USA aut Miller C. Department of Pathology, St. Louis Children's Hospital, Washington University in St. Louis, One Children Place, Suite 4S20, 63110, St. Louis, MO, USA aut Leonard J. Department of Neurosurgery, St. Louis Children's Hospital, Washington University in St. Louis, One Children Place, Suite 4S20, 63110, St. Louis, MO, USA aut Child's Nervous System Springer-Verlag 23/1(2007-01-01), 127-131 0256-7040 23:1<127 2007 23 381 https://doi.org/10.1007/s00381-006-0172-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00381-006-0172-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vadivelu S. Department of Neurosurgery, St. Louis Children's Hospital, Washington University in St. Louis, One Children Place, Suite 4S20, 63110, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Mangano F. Department of Neurosurgery, St. Louis Children's Hospital, Washington University in St. Louis, One Children Place, Suite 4S20, 63110, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Miller C. Department of Pathology, St. Louis Children's Hospital, Washington University in St. Louis, One Children Place, Suite 4S20, 63110, St. Louis, MO, USA aut NATIONALLICENCE 700 1- Leonard J. Department of Neurosurgery, St. Louis Children's Hospital, Washington University in St. Louis, One Children Place, Suite 4S20, 63110, St. Louis, MO, USA aut NATIONALLICENCE 773 0- Child's Nervous System Springer-Verlag 23/1(2007-01-01), 127-131 0256-7040 23:1<127 2007 23 381 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer