caa a22 4500 463179099 CHVBK 20180406164833.0 cr unu---uuuuu 170326e20070101xx s 000 0 eng 10.1007/s00381-006-0160-1 doi (NATIONALLICENCE)springer-10.1007/s00381-006-0160-1 Germinoma located in the basal ganglia in an 8-year-old girl [Elektronische Daten] [O. Klein, J. Voirin, T. Civit, J. Auque, J. Marchal] Case report: The authors describe a unique case of an 8-year-old girl with a germinoma located in the left basal ganglia. Medical history begins 5months before with a central diabetes insipidus, loss of weight (5kg at admission), vomiting and asthenia. Computed tomography (CT) and cranial magnetic resonance imaging (MRI) are performed and demonstrate a left basal ganglia tumour (nucleus lentiformis). Diabetes insipidus is considered as non-visible germinoma localization on the pituitary stalk rather than as a possible consequence of peri-tumoural oedema surrounding the hypothalamus. Spinal MRI is normal. Neurological as well as general examination is normal. Discussion: The first hypothesis is low-grade glioma, but pathological examination following a stereotactic biopsy of the lesion reveals a cerebral germinoma. A few days before the biopsy, the girl experienced a mild left facial palsy, and CT scans at the time of biopsy reveals an intra-tumoural haemorrhage. Alpha fetoprotein and human chorionic gonadotrophin were negative as blood and cerebrospinal fluid markers, whereas placental alkaline phosphatase was positive on immunohistochemical profile of the tumour samples. Dedicated chemotherapy, followed by focal irradiation (40Gy, 30 sessions, 45days; SIOP CNS GCT 93 protocol), is performed with a complete response. The outcome is good (Glasgow Outcome Scale=I), without any cognitive impairment and the persistence of a mild facial palsy and a slight right arm dystonia on last neurological examination. There is still no evidence of tumour recurrence. Springer-Verlag, 2006 Cerebral germinoma nationallicence Basal ganglia nationallicence Children nationallicence Chemotherapy nationallicence Radiation therapy nationallicence Klein O. Department of Neurosurgery, Hôpital Central, 29, Avenue du Maréchal de Lattre de Tassigny, 54035, Nancy Cedex, France aut Voirin J. Department of Neurosurgery, Hôpital Central, 29, Avenue du Maréchal de Lattre de Tassigny, 54035, Nancy Cedex, France aut Civit T. Department of Neurosurgery, Hôpital Central, 29, Avenue du Maréchal de Lattre de Tassigny, 54035, Nancy Cedex, France aut Auque J. Department of Neurosurgery, Hôpital Central, 29, Avenue du Maréchal de Lattre de Tassigny, 54035, Nancy Cedex, France aut Marchal J. Department of Neurosurgery, Hôpital Central, 29, Avenue du Maréchal de Lattre de Tassigny, 54035, Nancy Cedex, France aut Child's Nervous System Springer-Verlag 23/1(2007-01-01), 105-108 0256-7040 23:1<105 2007 23 381 https://doi.org/10.1007/s00381-006-0160-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00381-006-0160-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Klein O. Department of Neurosurgery, Hôpital Central, 29, Avenue du Maréchal de Lattre de Tassigny, 54035, Nancy Cedex, France aut NATIONALLICENCE 700 1- Voirin J. Department of Neurosurgery, Hôpital Central, 29, Avenue du Maréchal de Lattre de Tassigny, 54035, Nancy Cedex, France aut NATIONALLICENCE 700 1- Civit T. Department of Neurosurgery, Hôpital Central, 29, Avenue du Maréchal de Lattre de Tassigny, 54035, Nancy Cedex, France aut NATIONALLICENCE 700 1- Auque J. Department of Neurosurgery, Hôpital Central, 29, Avenue du Maréchal de Lattre de Tassigny, 54035, Nancy Cedex, France aut NATIONALLICENCE 700 1- Marchal J. Department of Neurosurgery, Hôpital Central, 29, Avenue du Maréchal de Lattre de Tassigny, 54035, Nancy Cedex, France aut NATIONALLICENCE 773 0- Child's Nervous System Springer-Verlag 23/1(2007-01-01), 105-108 0256-7040 23:1<105 2007 23 381 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer