caa a22 4500 463179137 CHVBK 20180406164833.0 cr unu---uuuuu 170326e20070601xx s 000 0 eng 10.1007/s00381-007-0326-5 doi (NATIONALLICENCE)springer-10.1007/s00381-007-0326-5 Endocrine evaluation after endoscopic third ventriculostomy (ETV) in children [Elektronische Daten] [M. Fritsch, M. Bauer, C. Partsch, W. Sippell, H. Mehdorn] Objective: Endoscopic third ventriculostomy (ETV) is a standard procedure for the treatment of obstructive hydrocephalus in children. Main part of the procedure is the perforation of the third ventricle floor (tuber cinereum). This structure is part of the hypothalamic-pituitary neuronal network of cerebral endocrine regulation. There are no systematic data available about the endocrine status after ETV in children. Materials and methods: We examined 20 children who had undergone ETV. Examination included laboratory tests (adrenocorticotropic hormone, prolactin, insulin-like growth factor 1 [IGF-1], IGF-binding protein 3 [IGFBP-3], fT3, fT4, thyroid-stimulating hormone [TSH], serum osmolarity, electrolytes, glucose, urea, follicle-stimulating hormone [FSH] and luteinizing hormone [LH], and testosterone in selected patients), measurement of weight, height, and head circumference, and physical examination. The study was approved by the Ethics Committee of the Medical Faculty of Kiel University. Results: In seven patients, prolactin was moderately elevated. One patient demonstrated a significantly increased prolactin (56.3ng/ml). In all eight patients, this was the only laboratory value that was out of the normal range; all other parameters were normal. Three other patients showed one abnormal parameter (decrease in FSH and LH, increase in TSH, decrease in IGF-1 and IGFBP-3). In nine patients, weight or height was not within the 3rd to 97th centiles for age. Discussion and conclusion: More patients than expected demonstrated endocrine laboratory abnormalities. However, there was no clinical relevance in any of the studied patients. It remains inconclusive whether ETV contributes to the abnormalities of prolactin levels or to other endocrine parameters in pediatric patients. Longitudinal studies are necessary to delineate the effect of ETV on endocrine regulation. Springer-Verlag, 2007 Endoscopic third ventriculostomy nationallicence Tuber cinereum nationallicence Prolactin nationallicence Fritsch M. Department of Neurosurgery, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Schittenhelmstr. 10, 24105, Kiel, Germany aut Bauer M. Department of Neurosurgery, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Schittenhelmstr. 10, 24105, Kiel, Germany aut Partsch C. Department of Pediatrics, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Schwanenweg 20, 24105, Kiel, Germany aut Sippell W. Department of Pediatrics, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Schwanenweg 20, 24105, Kiel, Germany aut Mehdorn H. Department of Neurosurgery, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Schittenhelmstr. 10, 24105, Kiel, Germany aut Child's Nervous System Springer-Verlag 23/6(2007-06-01), 627-631 0256-7040 23:6<627 2007 23 381 https://doi.org/10.1007/s00381-007-0326-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00381-007-0326-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fritsch M. Department of Neurosurgery, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Schittenhelmstr. 10, 24105, Kiel, Germany aut NATIONALLICENCE 700 1- Bauer M. Department of Neurosurgery, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Schittenhelmstr. 10, 24105, Kiel, Germany aut NATIONALLICENCE 700 1- Partsch C. Department of Pediatrics, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Schwanenweg 20, 24105, Kiel, Germany aut NATIONALLICENCE 700 1- Sippell W. Department of Pediatrics, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Schwanenweg 20, 24105, Kiel, Germany aut NATIONALLICENCE 700 1- Mehdorn H. Department of Neurosurgery, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Schittenhelmstr. 10, 24105, Kiel, Germany aut NATIONALLICENCE 773 0- Child's Nervous System Springer-Verlag 23/6(2007-06-01), 627-631 0256-7040 23:6<627 2007 23 381 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer