caa a22 4500 463179196 CHVBK 20180406164834.0 cr unu---uuuuu 170326e20070601xx s 000 0 eng 10.1007/s00381-007-0331-8 doi (NATIONALLICENCE)springer-10.1007/s00381-007-0331-8 Peri-operative quality of life assessment in endoscopically treated patients with pineal region tumours [Elektronische Daten] [Wuttipong Tirakotai, Thomas Riegel, Alex Stiegel, Dieter Hellwig, Stefan Heinze, Helmut Bertalanffy, Ilhan Celik] Background: Therapeutic modalities for pineal region tumours are still matter of debate. Endoscopic treatment is a minimally invasive approach. The aim of this study was to assess the quality of life of patients with pineal region tumours who underwent endoscopic procedures. Materials and methods: Eight patients (male:3, female 5) were included in this study. Post-operative evaluation of surgical outcome in terms of quality of life (QoL) was performed using the Quality of Life Questionnaire (QLQ-C30). The patient's outcome scores were compared with normative outcome values of the German population. Pre-operative and post-operative global QoL and symptoms such as headache, visual disturbance, gait disturbance, cognitive function and unconsciousness were documented. Descriptive and explorative statistics were performed. Results: There were no significant differences between the normal German population and the endoscopically treated patients in different health domains and measures of QLQ-C30 (physical functioning 87.5%, emotional functioning 50%, cognitive functioning 50%, social functioning 62.5%; percentage represents regular functioning). Improved quality of life could be demonstrated in short-term (3-12months, n = 3) and long-term (21-29months, n = 5) follow-up. Global QoL improved significantly (p < 0.001; t-test) post-operatively. The following changes between pre-operative and post-operative clinical symptoms were found (headache 87.5%/62.5%, visual disturbance 50%/25%, gait disturbance 87.5%/25%, cognitive functioning 75%/37.5%, unconsciousness 25%/-). Conclusion: Endoscopic treatment of patients with pineal region tumours produces improved post-operative quality of life in all health domains. Therefore, the endoscopic approach should be considered as an alternative treatment in patients with newly diagnosed pineal tumours and/or related hydrocephalus. Springer-Verlag, 2007 Brain tumour nationallicence Endoscopic neurosurgery nationallicence Neuroendoscopy nationallicence Post-operative outcome assessment nationallicence Quality of life nationallicence Tirakotai Wuttipong Department of Neurosurgery, Philipps University, Baldingerstrasse, 35033, Marburg, Germany aut Riegel Thomas Department of Neurosurgery, Philipps University, Baldingerstrasse, 35033, Marburg, Germany aut Stiegel Alex Department of Neurosurgery, Philipps University, Baldingerstrasse, 35033, Marburg, Germany aut Hellwig Dieter Department of Neurosurgery, Philipps University, Baldingerstrasse, 35033, Marburg, Germany aut Heinze Stefan Department of Neurosurgery, Philipps University, Baldingerstrasse, 35033, Marburg, Germany aut Bertalanffy Helmut Department of Neurosurgery, Philipps University, Baldingerstrasse, 35033, Marburg, Germany aut Celik Ilhan Institute of Theoretical Surgery, Philipps University, Marburg, Germany aut Child's Nervous System Springer-Verlag 23/6(2007-06-01), 659-663 0256-7040 23:6<659 2007 23 381 https://doi.org/10.1007/s00381-007-0331-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00381-007-0331-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tirakotai Wuttipong Department of Neurosurgery, Philipps University, Baldingerstrasse, 35033, Marburg, Germany aut NATIONALLICENCE 700 1- Riegel Thomas Department of Neurosurgery, Philipps University, Baldingerstrasse, 35033, Marburg, Germany aut NATIONALLICENCE 700 1- Stiegel Alex Department of Neurosurgery, Philipps University, Baldingerstrasse, 35033, Marburg, Germany aut NATIONALLICENCE 700 1- Hellwig Dieter Department of Neurosurgery, Philipps University, Baldingerstrasse, 35033, Marburg, Germany aut NATIONALLICENCE 700 1- Heinze Stefan Department of Neurosurgery, Philipps University, Baldingerstrasse, 35033, Marburg, Germany aut NATIONALLICENCE 700 1- Bertalanffy Helmut Department of Neurosurgery, Philipps University, Baldingerstrasse, 35033, Marburg, Germany aut NATIONALLICENCE 700 1- Celik Ilhan Institute of Theoretical Surgery, Philipps University, Marburg, Germany aut NATIONALLICENCE 773 0- Child's Nervous System Springer-Verlag 23/6(2007-06-01), 659-663 0256-7040 23:6<659 2007 23 381 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer