caa a22 4500 463179382 CHVBK 20180406164834.0 cr unu---uuuuu 170326e20070901xx s 000 0 eng 10.1007/s00381-007-0382-x doi (NATIONALLICENCE)springer-10.1007/s00381-007-0382-x Deep brain stimulation for torsion dystonia in children [Elektronische Daten] [Ron Alterman, Michele Tagliati] Introduction: Deep brain stimulation (DBS) at the internal globus pallidus (GPi) is an effective treatment for some patients with medically refractory torsion dystonia. In this article, we review the results of pallidal DBS surgery in children with dystonia. Details of the DBS procedure and programming of the DBS devices are discussed. Discussion: Pallidal DBS is most effective in patients with primary generalized dystonia. Children and adolescents possessing the DYT1 gene mutation may respond best of all. The presence of static dystonic postures and/or fixed orthopedic contractures may limit the functional response to DBS and may require additional surgery. Conclusion: As a group, patients with secondary dystonias respond less well to DBS than patients with primary dystonia. However, patients with dystonia secondary to anoxic brain injury who have grossly intact basal ganglia anatomy may represent a subpopulation for whom pallidal DBS is a viable option. Springer-Verlag, 2007 Deep brain stimulation nationallicence Dystonia nationallicence Globus pallidus nationallicence DYT1 nationallicence Stereotactic surgery nationallicence Alterman Ron Department of Neurosurgery, Mount Sinai Medical Center, One Gustave L. Levy Place, P.O. Box 1136, 10029, New York, NY, USA aut Tagliati Michele Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA aut Child's Nervous System Springer-Verlag 23/9(2007-09-01), 1033-1040 0256-7040 23:9<1033 2007 23 381 https://doi.org/10.1007/s00381-007-0382-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00381-007-0382-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Alterman Ron Department of Neurosurgery, Mount Sinai Medical Center, One Gustave L. Levy Place, P.O. Box 1136, 10029, New York, NY, USA aut NATIONALLICENCE 700 1- Tagliati Michele Department of Neurology, Mount Sinai School of Medicine, New York, NY, USA aut NATIONALLICENCE 773 0- Child's Nervous System Springer-Verlag 23/9(2007-09-01), 1033-1040 0256-7040 23:9<1033 2007 23 381 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer