caa a22 4500 463179463 CHVBK 20180406164834.0 cr unu---uuuuu 170326e20070901xx s 000 0 eng 10.1007/s00381-007-0409-3 doi (NATIONALLICENCE)springer-10.1007/s00381-007-0409-3 Apoptosis in alpha interferon (IFN-α) intratumoral chemotherapy for cystic craniopharyngiomas [Elektronische Daten] [D. Ierardi, M. Fernandes, I. Silva, J. Thomazini-Gouveia, N. Silva, P. Dastoli, S. Toledo, S. Cavalheiro] Objectives: The aim of this study was to verify whether intracystic injections of alpha-Interferon (IFN-α) in cystic craniopharyngiomas were able to reduce the tumor by activating the Fas apoptotic pathway. Materials and methods: Twenty-one patients with cystic craniopharyngiomas treated at the Pediatric Oncology Institute (IOP/GRAACC) of Federal University of São Paulo were submitted to intracystic chemotherapy with IFN-α. The tumor sizes of all patients were monitored and the apoptotic factor soluble FasL (sFasL) concentration was determined by ELISA (enzyme-linked immunosorbent assay) in tumor fluid samples from eight patients. Results: There was a complete reduction in 11 patients, a partial response in seven, and a minor response in three patients. The concentration of sFasL was increased in all the eight patients examined concomitantly with the tumor size reduction. Conclusions: Our data demonstrated that the IFN-α was able to induce Fas-mediated apoptosis together with a reduction in the tumor size; such an observation may suggest the importance to investigate still unexplored mechanisms to be exploited in craniopharyngioma therapy. Springer-Verlag, 2007 Cystic craniopharyngioma nationallicence Alpha interferon nationallicence Apoptosis nationallicence Fas/FasL pathway nationallicence Intratumoral chemotherapy nationallicence Cell death pathways nationallicence Ommaya reservoir nationallicence Ierardi D. Department of Neurology and Neurosurgery,Pediatric Oncology Institute, Federal University of São Paulo, Rua Botucatu 743, 8° andar, 04023-062, São Paulo, SP, Brazil aut Fernandes M. Department of Neurology and Neurosurgery, Federal University of São Paulo,Epilepsy Neurobiology Laboratory, Rua Pedro de Toledo, 781, 6° andar, 04039-032, São Paulo, SP, Brazil aut Silva I. Department of Neurology and Neurosurgery, Federal University of São Paulo,Epilepsy Neurobiology Laboratory, Rua Pedro de Toledo, 781, 6° andar, 04039-032, São Paulo, SP, Brazil aut Thomazini-Gouveia J. Pediatric Oncology Institute, Federal University of São Paulo, Rua Botucatu 743, 8° andar, 04023-062, São Paulo, SP, Brazil aut Silva N. Department of Pediatrics, Pediatric Oncology Institute, Federal University of São Paulo, Rua Botucatu 743, 8° andar, 04023-062, São Paulo, SP, Brazil aut Dastoli P. Department of Neurology and Neurosurgery,Pediatric Oncology Institute, Federal University of São Paulo, Rua Botucatu 743, 8° andar, 04023-062, São Paulo, SP, Brazil aut Toledo S. Department of Genetics, Pediatric Oncology Institute, Federal University of São Paulo, Rua Botucatu 743, 8° andar, 04023-062, São Paulo, SP, Brazil aut Cavalheiro S. Department of Neurology and Neurosurgery, Pediatric Oncology Institute, Federal University of São Paulo, Rua Botucatu 591/42, 04023-062, São Paulo, SP, Brazil aut Child's Nervous System Springer-Verlag 23/9(2007-09-01), 1041-1046 0256-7040 23:9<1041 2007 23 381 https://doi.org/10.1007/s00381-007-0409-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00381-007-0409-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ierardi D. Department of Neurology and Neurosurgery,Pediatric Oncology Institute, Federal University of São Paulo, Rua Botucatu 743, 8° andar, 04023-062, São Paulo, SP, Brazil aut NATIONALLICENCE 700 1- Fernandes M. Department of Neurology and Neurosurgery, Federal University of São Paulo,Epilepsy Neurobiology Laboratory, Rua Pedro de Toledo, 781, 6° andar, 04039-032, São Paulo, SP, Brazil aut NATIONALLICENCE 700 1- Silva I. Department of Neurology and Neurosurgery, Federal University of São Paulo,Epilepsy Neurobiology Laboratory, Rua Pedro de Toledo, 781, 6° andar, 04039-032, São Paulo, SP, Brazil aut NATIONALLICENCE 700 1- Thomazini-Gouveia J. Pediatric Oncology Institute, Federal University of São Paulo, Rua Botucatu 743, 8° andar, 04023-062, São Paulo, SP, Brazil aut NATIONALLICENCE 700 1- Silva N. Department of Pediatrics, Pediatric Oncology Institute, Federal University of São Paulo, Rua Botucatu 743, 8° andar, 04023-062, São Paulo, SP, Brazil aut NATIONALLICENCE 700 1- Dastoli P. Department of Neurology and Neurosurgery,Pediatric Oncology Institute, Federal University of São Paulo, Rua Botucatu 743, 8° andar, 04023-062, São Paulo, SP, Brazil aut NATIONALLICENCE 700 1- Toledo S. Department of Genetics, Pediatric Oncology Institute, Federal University of São Paulo, Rua Botucatu 743, 8° andar, 04023-062, São Paulo, SP, Brazil aut NATIONALLICENCE 700 1- Cavalheiro S. Department of Neurology and Neurosurgery, Pediatric Oncology Institute, Federal University of São Paulo, Rua Botucatu 591/42, 04023-062, São Paulo, SP, Brazil aut NATIONALLICENCE 773 0- Child's Nervous System Springer-Verlag 23/9(2007-09-01), 1041-1046 0256-7040 23:9<1041 2007 23 381 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer