caa a22 4500 463179935 CHVBK 20180406164836.0 cr unu---uuuuu 170326e20070301xx s 000 0 eng 10.1007/s00381-006-0243-z doi (NATIONALLICENCE)springer-10.1007/s00381-006-0243-z Astrocytic tumors in children: treatment results from a single institution [Elektronische Daten] [Ali Varan, Canan Akyüz, Nejat Akalan, Lale Atahan, Figen Söylemezoglu, Ugur Selek, Bilgehan Yalçin, Tezer Kutluk, Münevver Büyükpamukçu] Objective: The aims of this study are to evaluate the patients with astrocytomas and to investigate survival rates and prognosis. Patients and methods: Five hundred fourteen patients diagnosed with brain tumor between 1972 and 2003 were retrospectively analyzed. Three different chemotherapy regimens were used according to years. CCNU-based protocols were used in the early years; COPP (cyclophosphamide, oncovin, procarbazine, prednisolone) and CDDP+VP16 (cisplatinum + etoposide) were the other protocols used in the following years. Radiotherapy was used after 3years of age according to protocols. Results: Ninety-eight (19%) out of 514 patients have astrocytic histopathology. The histopathologic distribution was as follows: low grade, 55 patients; high grade, 43 patients. COPP regimen was given to 24 patients, CCNU-based regimen to 13, and CDDP+VP16 to 10 patients. We did not use any chemotherapy in 51 patients. Overall survival (OS) and event free-survival rates were 59.2 and 45.7% in whole group. OS rates were 93.3 and 22.4% for low-grade and high-grade histopathology, respectively (p=0.0001). OS for CCNU, CDDP+VP16, and COPP were 35.9, 22.8, and 30.4%, respectively. Conclusion: Low-grade astrocytomas are highly responsive to the surgery, and they do not need any further treatment unless the patient has relapse or recurrence. Still, the treatment of the high-grade tumors is a problem, and it needs new treatment approaches. Springer-Verlag, 2006 Astrocytic tumors nationallicence Children nationallicence Treatment nationallicence Prognosis nationallicence Varan Ali Department of Pediatric Oncology, Institute of Oncology, Hacettepe University, 06100, Ankara, Turkey aut Akyüz Canan Department of Pediatric Oncology, Institute of Oncology, Hacettepe University, 06100, Ankara, Turkey aut Akalan Nejat Department of Neurosurgery, Faculty of Medicine, Hacettepe University, 06100, Ankara, Turkey aut Atahan Lale Department of Radiation Oncology, Faculty of Medicine, Hacettepe University, 06100, Ankara, Turkey aut Söylemezoglu Figen Department of Pathology, Faculty of Medicine, Hacettepe University, 06100, Ankara, Turkey aut Selek Ugur Department of Radiation Oncology, Faculty of Medicine, Hacettepe University, 06100, Ankara, Turkey aut Yalçin Bilgehan Department of Pediatric Oncology, Institute of Oncology, Hacettepe University, 06100, Ankara, Turkey aut Kutluk Tezer Department of Pediatric Oncology, Institute of Oncology, Hacettepe University, 06100, Ankara, Turkey aut Büyükpamukçu Münevver Department of Pediatric Oncology, Institute of Oncology, Hacettepe University, 06100, Ankara, Turkey aut Child's Nervous System Springer-Verlag 23/3(2007-03-01), 315-319 0256-7040 23:3<315 2007 23 381 https://doi.org/10.1007/s00381-006-0243-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00381-006-0243-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Varan Ali Department of Pediatric Oncology, Institute of Oncology, Hacettepe University, 06100, Ankara, Turkey aut NATIONALLICENCE 700 1- Akyüz Canan Department of Pediatric Oncology, Institute of Oncology, Hacettepe University, 06100, Ankara, Turkey aut NATIONALLICENCE 700 1- Akalan Nejat Department of Neurosurgery, Faculty of Medicine, Hacettepe University, 06100, Ankara, Turkey aut NATIONALLICENCE 700 1- Atahan Lale Department of Radiation Oncology, Faculty of Medicine, Hacettepe University, 06100, Ankara, Turkey aut NATIONALLICENCE 700 1- Söylemezoglu Figen Department of Pathology, Faculty of Medicine, Hacettepe University, 06100, Ankara, Turkey aut NATIONALLICENCE 700 1- Selek Ugur Department of Radiation Oncology, Faculty of Medicine, Hacettepe University, 06100, Ankara, Turkey aut NATIONALLICENCE 700 1- Yalçin Bilgehan Department of Pediatric Oncology, Institute of Oncology, Hacettepe University, 06100, Ankara, Turkey aut NATIONALLICENCE 700 1- Kutluk Tezer Department of Pediatric Oncology, Institute of Oncology, Hacettepe University, 06100, Ankara, Turkey aut NATIONALLICENCE 700 1- Büyükpamukçu Münevver Department of Pediatric Oncology, Institute of Oncology, Hacettepe University, 06100, Ankara, Turkey aut NATIONALLICENCE 773 0- Child's Nervous System Springer-Verlag 23/3(2007-03-01), 315-319 0256-7040 23:3<315 2007 23 381 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer