caa a22 4500 463180011 CHVBK 20180406164836.0 cr unu---uuuuu 170326e20070301xx s 000 0 eng 10.1007/s00381-006-0251-z doi (NATIONALLICENCE)springer-10.1007/s00381-006-0251-z Neurodevelopment of children with single suture craniosynostosis: a review [Elektronische Daten] [Kathleen Kapp-Simon, Matthew Speltz, Michael Cunningham, Pravin Patel, Tadanori Tomita] Introduction: Rates of neurocognitive risk range from 35-50% of school-aged children with isolated single suture craniosynostosis (SSC). It has been hypothesized that early surgical intervention to release suture fusion reduces risk for increased intracranial pressure (ICP) and the corresponding risk to neurodevelopment. However, studies assessing children with SSC have been inconsistent in finding an association between neurocognitive development, age of surgery, and ICP. Review: SSC produces notable distortion of the cranial vault and underlying brain mass. Although a linear relationship between skull distortion, ICP, and neurocognitive deficits has generally been assumed, recent studies have postulated an interactive process between the skull and developing brain that results in neuroanatomical changes that are not limited to areas directly beneath the fused suture. The specific neuropsychological deficits identified in children with SSC including problems with attention and planning, processing speed, visual spatial skills, language, reading, and spelling may be related to the anatomic differences that persist after correction of suture fusion. Conclusions: Available literature on neurocognitive development of children with SSC is suggestive of mild but persistent neuropsychological deficits, which become more significant as cognitive demands increase at school age. Anatomical studies of children without SSC are beginning to identify particular groups of brain structures that if disrupted or malformed, may be associated with specific cognitive deficits. Controlled research investigating the relationship between persistent anatomical changes and neurocognitive functioning of school-aged children with SSC is needed. Springer-Verlag, 2006 Single suture craniosynostosis nationallicence Neurodevelopment nationallicence Cognition nationallicence Increased cranial pressure nationallicence Neuroimaging nationallicence Kapp-Simon Kathleen Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA aut Speltz Matthew Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA aut Cunningham Michael Children's Craniofacial Center, Children's Hospital and Regional Medical Center, Seattle, WA, USA aut Patel Pravin Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA aut Tomita Tadanori Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA aut Child's Nervous System Springer-Verlag 23/3(2007-03-01), 269-281 0256-7040 23:3<269 2007 23 381 https://doi.org/10.1007/s00381-006-0251-z text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00381-006-0251-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kapp-Simon Kathleen Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA aut NATIONALLICENCE 700 1- Speltz Matthew Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA aut NATIONALLICENCE 700 1- Cunningham Michael Children's Craniofacial Center, Children's Hospital and Regional Medical Center, Seattle, WA, USA aut NATIONALLICENCE 700 1- Patel Pravin Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA aut NATIONALLICENCE 700 1- Tomita Tadanori Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA aut NATIONALLICENCE 773 0- Child's Nervous System Springer-Verlag 23/3(2007-03-01), 269-281 0256-7040 23:3<269 2007 23 381 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer