caa a22 4500 46318002X CHVBK 20180406164836.0 cr unu---uuuuu 170326e20070301xx s 000 0 eng 10.1007/s00381-006-0221-5 doi (NATIONALLICENCE)springer-10.1007/s00381-006-0221-5 Proton magnetic resonance spectroscopy in childhood brainstem lesions [Elektronische Daten] [L. Porto, E. Hattingen, U. Pilatus, M. Kieslich, B. Yan, D. Schwabe, F. Zanella, H. Lanfermann] Background: Diagnosis of brainstem lesions in children based on magnetic resonance imaging alone is a challenging problem. Magnetic resonance spectroscopy (MRS) is a noninvasive technique for spatial characterization of biochemical markers in tissues and gives information regarding cell membrane proliferation, neuronal damage, and energy metabolism. Methods: We measured the concentrations of biochemical markers in five children with brainstem lesions and evaluated their potential diagnostic significance. Images and spectra were acquired on a 1.5-T imager. The concentrations of N-acetylaspartate, tetramethylamines (e.g., choline), creatine, phosphocreatine, lactate, and lipids were measured within lesions located at the brainstem using Point-resolved spectroscopy sequences. Results: Diagnosis based on localized proton spectroscopy included brainstem glioma, brainstem encephalitis, demyelination, dysmyelination secondary to neurofibromatosis type 1 (NF 1), and possible infection or radiation necrosis. In all but one patient, diagnosis was confirmed by biopsy or by clinical follow-up. Conclusions: This small sample of patients suggests that MRS is important in the differential diagnosis between proliferative and nonproliferative lesions in patients without neurofibromatosis. Unfortunately, in cases of NF 1, MRS can have a rather misdiagnosis role. Springer-Verlag, 2006 Brainstem lesions nationallicence 1H MR spectroscopy nationallicence Magnetic resonance imaging nationallicence Children nationallicence Brainstem glioma nationallicence Brainstem encephalitis nationallicence Neurofibromatosis type 1 nationallicence Porto L. Neuroradiology Department, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany aut Hattingen E. Neuroradiology Department, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany aut Pilatus U. Neuroradiology Department, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany aut Kieslich M. Neuropediatric Department, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany aut Yan B. Neuroradiology Department, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany aut Schwabe D. Pediatric Hematology/Oncology Department, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany aut Zanella F. Neuroradiology Department, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany aut Lanfermann H. Neuroradiology Department, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany aut Child's Nervous System Springer-Verlag 23/3(2007-03-01), 305-314 0256-7040 23:3<305 2007 23 381 https://doi.org/10.1007/s00381-006-0221-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00381-006-0221-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Porto L. Neuroradiology Department, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany aut NATIONALLICENCE 700 1- Hattingen E. Neuroradiology Department, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany aut NATIONALLICENCE 700 1- Pilatus U. Neuroradiology Department, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany aut NATIONALLICENCE 700 1- Kieslich M. Neuropediatric Department, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany aut NATIONALLICENCE 700 1- Yan B. Neuroradiology Department, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany aut NATIONALLICENCE 700 1- Schwabe D. Pediatric Hematology/Oncology Department, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany aut NATIONALLICENCE 700 1- Zanella F. Neuroradiology Department, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany aut NATIONALLICENCE 700 1- Lanfermann H. Neuroradiology Department, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany aut NATIONALLICENCE 773 0- Child's Nervous System Springer-Verlag 23/3(2007-03-01), 305-314 0256-7040 23:3<305 2007 23 381 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer