caa a22 4500 463180046 CHVBK 20180406164836.0 cr unu---uuuuu 170326e20070301xx s 000 0 eng 10.1007/s00381-006-0196-2 doi (NATIONALLICENCE)springer-10.1007/s00381-006-0196-2 Papillary glioneuronal tumour: a report of a rare case and review of literature [Elektronische Daten] [Surinder Atri, Mehar Sharma, Chitra Sarkar, Ajay Garg, Ashish Suri] Introduction: Amongst the mixed glioneuronal tumours, ‘papillary glioneuronal tumour', a new variant, has been described recently. Case report: We report a case of papillary glioneuronal tumour in a 4-year-old boy who presented with fever, weakness of left upper and lower limbs and headache for the last 2.5month. Radiologic examination showed a cystic space-occupying lesion with mural nodule in the right frontal lobe with extension into white matter. Surgical excision of a large cystic mass with small solid nodule was done. Pathological examination revealed a well-circumscribed tumour showing predominantly papillary architecture with focal aggregates of cells in sheets. The papillae were composed of hyalinised blood vessels lined by single to multi-layered cells. The tumour cells showed mild pleomorphism without any necrosis. The individual tumour cells had scant eosinophilic cytoplasm, round to oval hyperchromatic nucleus with occasional mitoses. The tumour cells were immunopositive for glial fibrillary acidic protein, synaptophysin, vimentin, and S-100 protein, but negative for neurofilament, epithelial membrane antigen, cytokeratin and CD34. MIB-1 labelling index was approximately 12% in the highest proliferating areas. In view of subtotal excision of the tumour and high MIB-1 labelling index (LI), the patient was given chemotherapy and he is doing well at 1-year follow-up. Discussion: This report supports the existence of this rare tumour. Some of its rare clinicopathological features like young age, cyst with mural nodule, presence of mitoses and raised MIB-1 LI need to be documented. Springer-Verlag, 2006 Papillary glioneuronal tumour nationallicence Pseudopapillary nationallicence Mixed glioneuronal tumour nationallicence Brain tumour nationallicence Atri Surinder Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India aut Sharma Mehar Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India aut Sarkar Chitra Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India aut Garg Ajay Department of Neuroradiology, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India aut Suri Ashish Department of Neurosurgery, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India aut Child's Nervous System Springer-Verlag 23/3(2007-03-01), 349-353 0256-7040 23:3<349 2007 23 381 https://doi.org/10.1007/s00381-006-0196-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00381-006-0196-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Atri Surinder Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India aut NATIONALLICENCE 700 1- Sharma Mehar Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India aut NATIONALLICENCE 700 1- Sarkar Chitra Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India aut NATIONALLICENCE 700 1- Garg Ajay Department of Neuroradiology, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India aut NATIONALLICENCE 700 1- Suri Ashish Department of Neurosurgery, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India aut NATIONALLICENCE 773 0- Child's Nervous System Springer-Verlag 23/3(2007-03-01), 349-353 0256-7040 23:3<349 2007 23 381 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer