caa a22 4500 463180119 CHVBK 20180406164836.0 cr unu---uuuuu 170326e20071001xx s 000 0 eng 10.1007/s00381-007-0344-3 doi (NATIONALLICENCE)springer-10.1007/s00381-007-0344-3 Prevalence of neural tube defects in economically and socially deprived area of China [Elektronische Daten] [Jie Liu, Guo Yang, Jin Zhou, Shi Cao, David Chau, Hsiang-fu Kung, Marie Lin] Objective: This paper aims to understand the situation and epidemiology trend of neural tube defects in Guizhou province, China from 1996 to 2004. Study design: Pregnant women from 17 hospitals in Guizhou province were chosen for investigation of perinatal infants from January 1996 to December 2004. Results: Of 1,208 birth defect cases studied in this 9-year period, a total of 122 cases were identified as neural tube defects (NTD), making up a 10.10% of the total birth defects. The average prevalence rate of NTD was 12.21 per 10,000 births; however, there is no significant difference between the genders. In this study, the age of mothers during pregnancy was shown to be one of the major factors affecting the prevalence rate of NTD and the differences between infants with or without NTD and the usage of folic acid as a supplement during pregnancy were found to be statistical significant. Conclusion: NTD was found to be the most common and serious form of human birth defect in Guizhou province. For prevention, folic acid supplement is thought to be efficacious in inhibiting NTD, and thus, it is essential for people in socially deprived areas to effectively reduce the prevalence of NTD in China. Springer-Verlag, 2007 Neural tube defects nationallicence Birth defects nationallicence Prevalence nationallicence Folic acid nationallicence Liu Jie Department of Chemistry and Open Laboratory of Chemical Biology, Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China aut Yang Guo Institute of Maternal and Child Health Care, Guiyang, Guizhou, China aut Zhou Jin Department of Obstetrics and Gynecology, First Affiliation Hospital of Guiyang Medical College, Guiyang, Guizhou Province, China aut Cao Shi Institute of Maternal and Child Health Care, Guiyang, Guizhou, China aut Chau David Department of Chemistry and Open Laboratory of Chemical Biology, Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China aut Kung Hsiang-fu Li Ka Shing Institute of Health Sciences and Centre for Emerging Infectious Disease, The Chinese University of Hong Kong, Hong Kong, China aut Lin Marie Department of Chemistry and Open Laboratory of Chemical Biology, Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China aut Child's Nervous System Springer-Verlag 23/10(2007-10-01), 1119-1124 0256-7040 23:10<1119 2007 23 381 https://doi.org/10.1007/s00381-007-0344-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00381-007-0344-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liu Jie Department of Chemistry and Open Laboratory of Chemical Biology, Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China aut NATIONALLICENCE 700 1- Yang Guo Institute of Maternal and Child Health Care, Guiyang, Guizhou, China aut NATIONALLICENCE 700 1- Zhou Jin Department of Obstetrics and Gynecology, First Affiliation Hospital of Guiyang Medical College, Guiyang, Guizhou Province, China aut NATIONALLICENCE 700 1- Cao Shi Institute of Maternal and Child Health Care, Guiyang, Guizhou, China aut NATIONALLICENCE 700 1- Chau David Department of Chemistry and Open Laboratory of Chemical Biology, Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China aut NATIONALLICENCE 700 1- Kung Hsiang-fu Li Ka Shing Institute of Health Sciences and Centre for Emerging Infectious Disease, The Chinese University of Hong Kong, Hong Kong, China aut NATIONALLICENCE 700 1- Lin Marie Department of Chemistry and Open Laboratory of Chemical Biology, Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China aut NATIONALLICENCE 773 0- Child's Nervous System Springer-Verlag 23/10(2007-10-01), 1119-1124 0256-7040 23:10<1119 2007 23 381 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer