caa a22 4500 463180143 CHVBK 20180406164836.0 cr unu---uuuuu 170326e20071001xx s 000 0 eng 10.1007/s00381-007-0374-x doi (NATIONALLICENCE)springer-10.1007/s00381-007-0374-x Chiari I malformation and idiopathic growth hormone deficiency in siblings: report of three cases [Elektronische Daten] [R. Murphy, R. Tubbs, Paul Grabb, W. Oakes] Introduction: The authors report a case of three brothers. Case descriptions: Two of these siblings presented with congenital growth hormone deficiency (GHD) and Chiari I malformation (CIM). The third younger brother has been found not to have GHD or the CIM. Discussion: Sparse cases of these two clinical occurrences have been reported. Further, the posterior cranial fossa (PF) has been determined to be altered in patients with CIM and GHD. Conclusion: Our current case reports strengthen the association between these two pathological entities and, to our knowledge, is the first description of both defects in siblings. Springer-Verlag, 2007 Hindbrain nationallicence Tonsillar ectopia nationallicence Posterior fossa nationallicence Murphy R. University of Alabama School of Medicine, Birmingham, AL, USA aut Tubbs R. Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL, USA aut Grabb Paul Pediatric Neurosurgery, Children's Hospital, 1600 7th Avenue South ACC 400, 35233, Birmingham, AL, USA aut Oakes W. Pediatric Neurosurgery, Children's Hospital, 1600 7th Avenue South ACC 400, 35233, Birmingham, AL, USA aut Child's Nervous System Springer-Verlag 23/10(2007-10-01), 1221-1223 0256-7040 23:10<1221 2007 23 381 https://doi.org/10.1007/s00381-007-0374-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00381-007-0374-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Murphy R. University of Alabama School of Medicine, Birmingham, AL, USA aut NATIONALLICENCE 700 1- Tubbs R. Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL, USA aut NATIONALLICENCE 700 1- Grabb Paul Pediatric Neurosurgery, Children's Hospital, 1600 7th Avenue South ACC 400, 35233, Birmingham, AL, USA aut NATIONALLICENCE 700 1- Oakes W. Pediatric Neurosurgery, Children's Hospital, 1600 7th Avenue South ACC 400, 35233, Birmingham, AL, USA aut NATIONALLICENCE 773 0- Child's Nervous System Springer-Verlag 23/10(2007-10-01), 1221-1223 0256-7040 23:10<1221 2007 23 381 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 462019322 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer