caa a22 4500 46318016X CHVBK 20180406164836.0 cr unu---uuuuu 170326e20071001xx s 000 0 eng 10.1007/s00381-007-0339-0 doi (NATIONALLICENCE)springer-10.1007/s00381-007-0339-0 Change in cerebral autoregulation as a function of time in children after severe traumatic brain injury: a case series [Elektronische Daten] [Nuj Tontisirin, William Armstead, Pichaya Waitayawinyu, Anne Moore, Yuthana Udomphorn, Jerry Zimmerman, Randall Chesnut, Monica Vavilala] Objective: The objective of this study was to describe changes in cerebral autoregulation after severe pediatric traumatic brain injury (TBI). Materials and methods: Two cerebral autoregulation tests were performed during the first 10days after severe TBI in children <16years. Cerebral autoregulation was quantified using the mean autoregulatory index (mARI). Results: Nine (five males/four females) children (10 ± 5years) with severe (admission Glasgow Coma Scale (GCS), 5 ± 2) TBI were enrolled. Thirty (3/9) percent of initial exams revealed impaired cerebral autoregulation; all three had returned to intact cerebral autoregulation on second exam. However, in three of nine (33%) patients, cerebral autoregulation worsened on second exam. Of the factors examined, worsening mARI on second exam was associated with worsening head computed tomography (CT) lesion. Conclusions: Cerebral autoregulation often changed and worsened during the first 9days after severe pediatric TBI. Worsening cerebral autoregulation may mirror worsening TBI. Springer-Verlag, 2007 Pediatric traumatic brain injury nationallicence Cerebral autoregulation nationallicence Cerebral blood flow nationallicence Pediatric trauma nationallicence Tontisirin Nuj Department of Anesthesiology, Harborview Medical Center, 325 Ninth Avenue, P.O. Box 359724, 98104, Seattle, WA, USA aut Armstead William Department of Anesthesiology, University of Pennsylvania, 3400 Spruce Street, 19104, Philadelphia, PA, USA aut Waitayawinyu Pichaya Department of Anesthesiology, Harborview Medical Center, 325 Ninth Avenue, P.O. Box 359724, 98104, Seattle, WA, USA aut Moore Anne Departments of Neurological Surgery, University of Washington, 1959 NE Pacific Street, 98195, Seattle, WA, USA aut Udomphorn Yuthana Department of Anesthesiology, Harborview Medical Center, 325 Ninth Avenue, P.O. Box 359724, 98104, Seattle, WA, USA aut Zimmerman Jerry Department of Anesthesiology, Harborview Medical Center, 325 Ninth Avenue, P.O. Box 359724, 98104, Seattle, WA, USA aut Chesnut Randall Departments of Neurological Surgery, University of Washington, 1959 NE Pacific Street, 98195, Seattle, WA, USA aut Vavilala Monica Department of Anesthesiology, Harborview Medical Center, 325 Ninth Avenue, P.O. Box 359724, 98104, Seattle, WA, USA aut Child's Nervous System Springer-Verlag 23/10(2007-10-01), 1163-1169 0256-7040 23:10<1163 2007 23 381 https://doi.org/10.1007/s00381-007-0339-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00381-007-0339-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tontisirin Nuj Department of Anesthesiology, Harborview Medical Center, 325 Ninth Avenue, P.O. Box 359724, 98104, Seattle, WA, USA aut NATIONALLICENCE 700 1- Armstead William Department of Anesthesiology, University of Pennsylvania, 3400 Spruce Street, 19104, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Waitayawinyu Pichaya Department of Anesthesiology, Harborview Medical Center, 325 Ninth Avenue, P.O. Box 359724, 98104, Seattle, WA, USA aut NATIONALLICENCE 700 1- Moore Anne Departments of Neurological Surgery, University of Washington, 1959 NE Pacific Street, 98195, Seattle, WA, USA aut NATIONALLICENCE 700 1- Udomphorn Yuthana Department of Anesthesiology, Harborview Medical Center, 325 Ninth Avenue, P.O. Box 359724, 98104, Seattle, WA, USA aut NATIONALLICENCE 700 1- Zimmerman Jerry Department of Anesthesiology, Harborview Medical Center, 325 Ninth Avenue, P.O. Box 359724, 98104, Seattle, WA, USA aut NATIONALLICENCE 700 1- Chesnut Randall Departments of Neurological Surgery, University of Washington, 1959 NE Pacific Street, 98195, Seattle, WA, USA aut NATIONALLICENCE 700 1- Vavilala Monica Department of Anesthesiology, Harborview Medical Center, 325 Ninth Avenue, P.O. Box 359724, 98104, Seattle, WA, USA aut NATIONALLICENCE 773 0- Child's Nervous System Springer-Verlag 23/10(2007-10-01), 1163-1169 0256-7040 23:10<1163 2007 23 381 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer