caa a22 4500 463180232 CHVBK 20180406164836.0 cr unu---uuuuu 170326e20071001xx s 000 0 eng 10.1007/s00381-007-0343-4 doi (NATIONALLICENCE)springer-10.1007/s00381-007-0343-4 Multiple pilocytic astrocytomas of the cerebellum in a 17-year-old patient with neurofibromatosis type I [Elektronische Daten] [Ian Dunn, Pankaj Agarwalla, Alexander Papanastassiou, William Butler, Edward Smith] Objective: Approximately 10% of patients with neurofibromatosis I (NFI) patients will have central nervous system (CNS) tumors. The most common of these are hypothalamic-optic gliomas, followed by brainstem and cerebellar pilocytic astrocytomas. While isolated pilocytic astrocytomas in NFI are well described, the appearance of multiple pilocytic astrocytomas in an individual patient is less common. The most frequent combination in NFI patients with more than one pilocytic astrocytoma is optic tract/hypothalamic and brainstem. Other combinations are exceedingly rare; multiple pilocytic astrocytomas have only been reported once in the cerebral hemispheres in a patient with NFI. This report presents the first documented case, to our knowledge, of multiple pilocytic astrocytomas in the cerebellum of a patient with NF1. Methods: Case report. Conclusion: The finding of multiple cerebellar pilocytic astrocytomas in a patient with NF1 is important because it expands the spectrum of presentations for patients with NF1 and also highlights specific diagnostic and therapeutic challenges faced by the treating physicians. The genetic and molecular basis of NF1 is reviewed. Strategies of diagnosis and treatment outlined here are relevant to both patients with NF1 and all patients with multiple posterior fossa tumors. Springer-Verlag, 2007 Neurofibromatosis I nationallicence Multiple pilocytic astrocytomas nationallicence Brain tumor nationallicence Pediatric nationallicence Dunn Ian Department of Neurosurgery, Children's Hospital Boston, 300 Longwood Avenue, 02115, Boston, MA, USA aut Agarwalla Pankaj Department of Neurosurgery, Children's Hospital Boston, 300 Longwood Avenue, 02115, Boston, MA, USA aut Papanastassiou Alexander Department of Neurosurgery, Children's Hospital Boston, 300 Longwood Avenue, 02115, Boston, MA, USA aut Butler William Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA aut Smith Edward Department of Neurosurgery, Children's Hospital Boston, 300 Longwood Avenue, 02115, Boston, MA, USA aut Child's Nervous System Springer-Verlag 23/10(2007-10-01), 1191-1194 0256-7040 23:10<1191 2007 23 381 https://doi.org/10.1007/s00381-007-0343-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00381-007-0343-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dunn Ian Department of Neurosurgery, Children's Hospital Boston, 300 Longwood Avenue, 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Agarwalla Pankaj Department of Neurosurgery, Children's Hospital Boston, 300 Longwood Avenue, 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Papanastassiou Alexander Department of Neurosurgery, Children's Hospital Boston, 300 Longwood Avenue, 02115, Boston, MA, USA aut NATIONALLICENCE 700 1- Butler William Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA aut NATIONALLICENCE 700 1- Smith Edward Department of Neurosurgery, Children's Hospital Boston, 300 Longwood Avenue, 02115, Boston, MA, USA aut NATIONALLICENCE 773 0- Child's Nervous System Springer-Verlag 23/10(2007-10-01), 1191-1194 0256-7040 23:10<1191 2007 23 381 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer