caa a22 4500 463180348 CHVBK 20180406164837.0 cr unu---uuuuu 170326e20070401xx s 000 0 eng 10.1007/s00381-006-0258-5 doi (NATIONALLICENCE)springer-10.1007/s00381-006-0258-5 Outcome of children with posterior fossa medulloblastoma: a single institution experience over the decade 1994-2003 [Elektronische Daten] [D. Kombogiorgas, S. Sgouros, A. Walsh, A. Hockley, M. Stevens, R. Grundy, A. Peet, M. English, D. Spooner] Aim: While the impact of radiotherapy in the management of medulloblastoma was recognised, the introduction of chemotherapy was investigated in clinical trials and shown to confer an additional advantage. We reviewed the outcome of a series of consecutive patients to assess the impact in a population-based clinical establishment. Materials and methods: A series of 38 children treated for medulloblastoma at Birmingham Children's Hospital between 1994 and 2003 was analysed. The effect of surgery, radiotherapy, chemotherapy and metastasis on survival was analysed. Results: The overall 5-year survival rate was 61.4% for the 36 patients who had resective surgery, while 2 patients had biopsy only and died within a few months. There was no operative mortality. The incidence of hydrocephalus needing permanent shunting was higher in the first 3years of life (p = 0.007, chi-square). The 5-year survival rate of patients with total and sub-total excision of medulloblastoma was 61.1% and 61.8%, respectively. The 5-year survival rate of patients older than 3years was 73.4% and for patients under 3years was 36.3% (p = 0.007, log rank). Metastases at presentation did not influence survival. All deaths occurred in the first 32months. Conclusion: The contribution of chemotherapy in the improvement of the overall survival appears more evident in children younger than 3years or presenting with metastases. The absence of significant difference in survival between patients with total or sub-total excision of medulloblastoma supports the view that total excision of medulloblastoma can be avoided when the risk for potential intra-operative damage and consequent neurological deficits is high. Springer-Verlag, 2006 Medulloblastoma nationallicence Surgery nationallicence Radiotherapy nationallicence Chemotherapy nationallicence Kombogiorgas D. Department of Neurosurgery, Birmingham Children's Hospital, Steelhouse Lane, B4 6NH, Birmingham, UK aut Sgouros S. Department of Neurosurgery, Birmingham Children's Hospital, Steelhouse Lane, B4 6NH, Birmingham, UK aut Walsh A. Department of Neurosurgery, Birmingham Children's Hospital, Steelhouse Lane, B4 6NH, Birmingham, UK aut Hockley A. Department of Neurosurgery, Birmingham Children's Hospital, Steelhouse Lane, B4 6NH, Birmingham, UK aut Stevens M. Department of Oncology, Bristol Children's Hospital, Bristol, UK aut Grundy R. Department of Oncology, Queen's Medical Centre, Nottingham, UK aut Peet A. Department of Oncology, Birmingham Children's Hospital, Birmingham, UK aut English M. Department of Oncology, Birmingham Children's Hospital, Birmingham, UK aut Spooner D. Department of Radiotherapy, Birmingham Children's Hospital, Birmingham, UK aut Child's Nervous System Springer-Verlag 23/4(2007-04-01), 399-405 0256-7040 23:4<399 2007 23 381 https://doi.org/10.1007/s00381-006-0258-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00381-006-0258-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kombogiorgas D. Department of Neurosurgery, Birmingham Children's Hospital, Steelhouse Lane, B4 6NH, Birmingham, UK aut NATIONALLICENCE 700 1- Sgouros S. Department of Neurosurgery, Birmingham Children's Hospital, Steelhouse Lane, B4 6NH, Birmingham, UK aut NATIONALLICENCE 700 1- Walsh A. Department of Neurosurgery, Birmingham Children's Hospital, Steelhouse Lane, B4 6NH, Birmingham, UK aut NATIONALLICENCE 700 1- Hockley A. Department of Neurosurgery, Birmingham Children's Hospital, Steelhouse Lane, B4 6NH, Birmingham, UK aut NATIONALLICENCE 700 1- Stevens M. Department of Oncology, Bristol Children's Hospital, Bristol, UK aut NATIONALLICENCE 700 1- Grundy R. Department of Oncology, Queen's Medical Centre, Nottingham, UK aut NATIONALLICENCE 700 1- Peet A. Department of Oncology, Birmingham Children's Hospital, Birmingham, UK aut NATIONALLICENCE 700 1- English M. Department of Oncology, Birmingham Children's Hospital, Birmingham, UK aut NATIONALLICENCE 700 1- Spooner D. Department of Radiotherapy, Birmingham Children's Hospital, Birmingham, UK aut NATIONALLICENCE 773 0- Child's Nervous System Springer-Verlag 23/4(2007-04-01), 399-405 0256-7040 23:4<399 2007 23 381 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer