caa a22 4500 463180380 CHVBK 20180406164837.0 cr unu---uuuuu 170326e20070401xx s 000 0 eng 10.1007/s00381-006-0282-5 doi (NATIONALLICENCE)springer-10.1007/s00381-006-0282-5 Pilot study of ifosfamide/carboplatin/etoposide (ICE) for peripheral blood stem cell mobilization in patients with high-risk or relapsed medulloblastoma [Elektronische Daten] [Shuichi Okada, Teruaki Hongo, Kimiyoshi Sakaguchi, Kazunori Suzuki, Shigeru Nishizawa, Takehiko Ohzeki] Objectives: The purpose of this study is to evaluate the stem cell mobilization capacity, anti-tumor effect, and feasibility of ifosfamide/carboplatin/etoposide (ICE) for transplant-eligible patients with medulloblastoma. Materials and methods: Six patients (23months to 18years old) with high-risk or relapsed medulloblastoma received one cycle of ICE, which consisted of ifosfamide at 1.8g/m2 for 5days, carboplatin 400mg/m2 for 2days, and etoposide 100mg/m2 for 5days. Stem cells were mobilized with ICE followed by granulocyte colony-stimulating factor at 10μg kg−1 day−1. Results: After one cycle of ICE, the median number of harvested CD34+ cells per apheresis session was 11.85 × 106 cells/kg (range, 0.2 to 71.2 × 106 cells/kg). Two patients obtained a complete response and three patients a partial response. All patients experienced severe myelosuppression, and three infectious toxicities were observed. Conclusions: These results suggest that ICE is optimal for mobilizing stem cells, effective for high-risk or relapsed medulloblastoma, and tolerable with limited non-hematological toxicity. Springer-Verlag, 2007 High-risk medulloblastoma nationallicence Relapsed medulloblastoma nationallicence Ifosfamide nationallicence Carboplatin nationallicence Etoposide nationallicence Peripheral blood stem cell mobilization nationallicence Okada Shuichi Department of Pediatrics, Hamamatsu University School of Medicine, Handayama 1-20-1, 431-3192, Hamamatsu, Japan aut Hongo Teruaki Department of Pediatrics, Hamamatsu University School of Medicine, Handayama 1-20-1, 431-3192, Hamamatsu, Japan aut Sakaguchi Kimiyoshi Department of Pediatrics, Hamamatsu University School of Medicine, Handayama 1-20-1, 431-3192, Hamamatsu, Japan aut Suzuki Kazunori Department of Radiology, Hamamatsu University School of Medicine, Hamamatsu, Japan aut Nishizawa Shigeru Department of Neurosurgery, Hamamatsu University School of Medicine, Hamamatsu, Japan aut Ohzeki Takehiko Department of Pediatrics, Hamamatsu University School of Medicine, Handayama 1-20-1, 431-3192, Hamamatsu, Japan aut Child's Nervous System Springer-Verlag 23/4(2007-04-01), 407-413 0256-7040 23:4<407 2007 23 381 https://doi.org/10.1007/s00381-006-0282-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00381-006-0282-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Okada Shuichi Department of Pediatrics, Hamamatsu University School of Medicine, Handayama 1-20-1, 431-3192, Hamamatsu, Japan aut NATIONALLICENCE 700 1- Hongo Teruaki Department of Pediatrics, Hamamatsu University School of Medicine, Handayama 1-20-1, 431-3192, Hamamatsu, Japan aut NATIONALLICENCE 700 1- Sakaguchi Kimiyoshi Department of Pediatrics, Hamamatsu University School of Medicine, Handayama 1-20-1, 431-3192, Hamamatsu, Japan aut NATIONALLICENCE 700 1- Suzuki Kazunori Department of Radiology, Hamamatsu University School of Medicine, Hamamatsu, Japan aut NATIONALLICENCE 700 1- Nishizawa Shigeru Department of Neurosurgery, Hamamatsu University School of Medicine, Hamamatsu, Japan aut NATIONALLICENCE 700 1- Ohzeki Takehiko Department of Pediatrics, Hamamatsu University School of Medicine, Handayama 1-20-1, 431-3192, Hamamatsu, Japan aut NATIONALLICENCE 773 0- Child's Nervous System Springer-Verlag 23/4(2007-04-01), 407-413 0256-7040 23:4<407 2007 23 381 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer