caa a22 4500 463180453 CHVBK 20180406164837.0 cr unu---uuuuu 170326e20070401xx s 000 0 eng 10.1007/s00381-006-0246-9 doi (NATIONALLICENCE)springer-10.1007/s00381-006-0246-9 Anaplastic oligoastrocytoma: previous treatment as a possible cause in a child with acute lymphoblastic leukemia [Elektronische Daten] [Necmettin Tanriover, Mustafa Ulu, Mehmet Sar, Mustafa Uzan] Introduction: The authors present a 14-year-old patient who developed an anaplastic oligoastrocytoma of the left parietal lobe 9years after a successful treatment of acute lymphoblastic leukemia (ALL). He had a history of induction chemotherapy, intrathecal methotrexate and prophylactic whole brain irradiation (1,800cGy in 10 fractions over 2weeks). Discussion: Radiation-induced neoplasia is suggested to be the late complication of ALL treatment, and evaluation of large clinical series revealed a relationship between young age at ALL diagnosis (<6years) and increased high-grade glioma occurrence risk. Conclusion: The authors have reviewed previously reported cases of secondary central nervous system malignancies focusing on age at ALL diagnosis, and they think that synergistic action of therapeutic modalities could have played a role in the oncogenetic process. Detailed systematic radiological follow-up should be done in these patients especially if a personal history of cranial irradiation is present. Springer-Verlag, 2006 Acute lymphoblastic leukemia nationallicence Anaplastic oligoastrocytoma nationallicence Methotrexate nationallicence Radiation nationallicence Secondary neoplasm nationallicence Tanriover Necmettin Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey aut Ulu Mustafa Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey aut Sar Mehmet Department of Pathology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey aut Uzan Mustafa Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey aut Child's Nervous System Springer-Verlag 23/4(2007-04-01), 469-473 0256-7040 23:4<469 2007 23 381 https://doi.org/10.1007/s00381-006-0246-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00381-006-0246-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tanriover Necmettin Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey aut NATIONALLICENCE 700 1- Ulu Mustafa Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey aut NATIONALLICENCE 700 1- Sar Mehmet Department of Pathology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey aut NATIONALLICENCE 700 1- Uzan Mustafa Department of Neurosurgery, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey aut NATIONALLICENCE 773 0- Child's Nervous System Springer-Verlag 23/4(2007-04-01), 469-473 0256-7040 23:4<469 2007 23 381 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer