caa a22 4500 463180542 CHVBK 20180406164837.0 cr unu---uuuuu 170326e20070801xx s 000 0 eng 10.1007/s00381-007-0336-3 doi (NATIONALLICENCE)springer-10.1007/s00381-007-0336-3 Lumbosacral glioblastoma and leptomeningeal gliomatosis complicating the course of a cervicothoracic astrocytoma WHO grade II [Elektronische Daten] [Daniel Klase, Stefan Gottschalk, Erich Reusche, Christian Hagel, Einar Goebel, Volker Tronnier, Alf Giese] Case report: The reported female patient underwent sub-total resection of an intra-medullary cervicothoracic astrocytoma classified as WHO grade II in 1984 at the age of 18 months and received local irradiation. In 1989, a local recurrence was diagnosed and a partial resection was performed. Sixteen years later, a small recurrent cervicothoracic tumour was found and spinal seeding to the equine nerve roots and the left cerebellar cortex was apparent on MRI. The patient was implanted with a ventriculoperitoneal shunt for a pseudo-tumour cerebri producing papilloedema, which eventually lead to amaurosis. After an extended biopsy, the invasive lumbosacral tumour was classified as glioblastoma multiforme. Two months later, the patient died after rapid progression of the caudal cranial nerve dysfunction. Discussion and conclusion: Anaplastic progression and dissemination of spinal astrocytomas even two decades after initial diagnosis and treatment are rare. Therapies and diagnostic follow-up strategies are discussed. Springer-Verlag, 2007 Glioblastoma nationallicence Spinal astrocytoma nationallicence Optic nerve atrophy nationallicence Papilloedema nationallicence Spinal gliomatosis nationallicence Klase Daniel Department of Neurosurgery, University of Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany aut Gottschalk Stefan Department of Neuroradiology, University of Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany aut Reusche Erich Department of Neuropathology, University of Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany aut Hagel Christian Department of Neuropathology, University Hospital Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany aut Goebel Einar Department of Neuroradiology, University Hospital Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany aut Tronnier Volker Department of Neurosurgery, University of Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany aut Giese Alf Department of Neurosurgery, Georg-August-University of Goettingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany aut Child's Nervous System Springer-Verlag 23/8(2007-08-01), 907-912 0256-7040 23:8<907 2007 23 381 https://doi.org/10.1007/s00381-007-0336-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00381-007-0336-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Klase Daniel Department of Neurosurgery, University of Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany aut NATIONALLICENCE 700 1- Gottschalk Stefan Department of Neuroradiology, University of Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany aut NATIONALLICENCE 700 1- Reusche Erich Department of Neuropathology, University of Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany aut NATIONALLICENCE 700 1- Hagel Christian Department of Neuropathology, University Hospital Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany aut NATIONALLICENCE 700 1- Goebel Einar Department of Neuroradiology, University Hospital Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany aut NATIONALLICENCE 700 1- Tronnier Volker Department of Neurosurgery, University of Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany aut NATIONALLICENCE 700 1- Giese Alf Department of Neurosurgery, Georg-August-University of Goettingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany aut NATIONALLICENCE 773 0- Child's Nervous System Springer-Verlag 23/8(2007-08-01), 907-912 0256-7040 23:8<907 2007 23 381 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer