caa a22 4500 46318064X CHVBK 20180406164838.0 cr unu---uuuuu 170326e20070801xx s 000 0 eng 10.1007/s00381-007-0334-5 doi (NATIONALLICENCE)springer-10.1007/s00381-007-0334-5 Prolonged exposure to antibiotic-impregnated shunt catheters does not increase incidence of late shunt infections [Elektronische Daten] [Daniel Sciubba, Matthew McGirt, Graeme Woodworth, Benjamin Carson, George Jallo] Objective: Antibiotic-impregnated shunt (AIS) systems have been designed to prevent the colonization of shunt components by skin flora that occurs at surgery. Although such systems may decrease the incidence of early shunt infections (those occurring within 6months of shunt placement), it is unclear if such exposure to prolonged antibiotics leads to an increased incidence or virulence of late shunt infections (those occurring later than 6months after shunt placement). In this study, the authors evaluate the incidence of late shunt infection after the introduction of an AIS system in a pediatric hydrocephalus population. Materials and methods: We prospectively reviewed all pediatric patients undergoing antibiotic-impregnated CSF shunt insertion or shunt revision operations at our institution for the 33month period between October 1, 2002 and June 31, 2005. All shunt-related complications, including shunt infection, were evaluated in those patients with later than 6months of follow-up. Results: A total of 153 pediatric patients (between 1 and 21years of age) underwent 262 shunting procedures involving the use of antibiotic-impregnated catheters. All patients were followed-up for later than 6months with a mean follow-up of 21.7months (range 13-46months). Ten patients (3.82%) experienced an early shunt infection within the 6-month follow-up period. No patients experienced a late shunt infection. Conclusion: Although concern exists that AIS systems may delay shunt infections or even increase the rate or virulence of such infections, introduction of such catheters into a pediatric hydrocephalus cohort does not significantly increase incidence of late CSF shunt infection compared to historic controls. Springer-Verlag, 2007 Antibiotic nationallicence Hydrocephalus nationallicence Infection nationallicence Shunts nationallicence Pediatric nationallicence Sciubba Daniel Department of Neurosurgery, Johns Hopkins School of Medicine, 600 North Wolfe Street, Meyer 8-161, 21287, Baltimore, MD, USA aut McGirt Matthew Department of Neurosurgery, Johns Hopkins School of Medicine, 600 North Wolfe Street, Meyer 8-161, 21287, Baltimore, MD, USA aut Woodworth Graeme Department of Neurosurgery, Johns Hopkins School of Medicine, 600 North Wolfe Street, Meyer 8-161, 21287, Baltimore, MD, USA aut Carson Benjamin Department of Neurosurgery, Johns Hopkins School of Medicine, 600 North Wolfe Street, Meyer 8-161, 21287, Baltimore, MD, USA aut Jallo George Department of Neurosurgery, Johns Hopkins School of Medicine, 600 North Wolfe Street, Meyer 8-161, 21287, Baltimore, MD, USA aut Child's Nervous System Springer-Verlag 23/8(2007-08-01), 867-871 0256-7040 23:8<867 2007 23 381 https://doi.org/10.1007/s00381-007-0334-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00381-007-0334-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sciubba Daniel Department of Neurosurgery, Johns Hopkins School of Medicine, 600 North Wolfe Street, Meyer 8-161, 21287, Baltimore, MD, USA aut NATIONALLICENCE 700 1- McGirt Matthew Department of Neurosurgery, Johns Hopkins School of Medicine, 600 North Wolfe Street, Meyer 8-161, 21287, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Woodworth Graeme Department of Neurosurgery, Johns Hopkins School of Medicine, 600 North Wolfe Street, Meyer 8-161, 21287, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Carson Benjamin Department of Neurosurgery, Johns Hopkins School of Medicine, 600 North Wolfe Street, Meyer 8-161, 21287, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Jallo George Department of Neurosurgery, Johns Hopkins School of Medicine, 600 North Wolfe Street, Meyer 8-161, 21287, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Child's Nervous System Springer-Verlag 23/8(2007-08-01), 867-871 0256-7040 23:8<867 2007 23 381 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer