caa a22 4500 463180860 CHVBK 20180406164838.0 cr unu---uuuuu 170326e20070501xx s 000 0 eng 10.1007/s00381-006-0289-y doi (NATIONALLICENCE)springer-10.1007/s00381-006-0289-y Retinoic acid-induced lumbosacral neural tube defects: myeloschisis and hamartoma [Elektronische Daten] [WeiSong Cai, HongYu Zhao, JunBin Guo, Yong Li, ZhengWei Yuan, WeiLin Wang] Objects: To observe the morphological features of the lumbosacral neural tube defects (NTDs) induced by all-trans retinoic acid (atRA) and to explore the pathogenesis of these defects. Methods: Rat embryos with lumbosacral NTDs were obtained by treating pregnant rats with administration of atRA. Rat embryos were obtained by cesarean. Fetuses were sectioned and stained with hematoxylin-eosin (H&E). Relevant structures including caudal neural tube were examined. In the atRA-treated rats, about 48% embryos showed lumbosacral NTDs. There appeared a dorsally and rostrally situated, neural-plate-like structure (myeloschisis) and a ventrally and caudally located cell mass containing multiple canals (hamartoma) in the lumbosacral NTDs induced by atRA. Conclusions: Retinoic acid could disturb the notochord and tail bud development in the process of primary and secondary neurulation in rat embryos, which cause lumbosacral NTDs including myeloschisis and hamartoma. The morphology is very similar to that happens in humans. Springer-Verlag, 2007 Neural tube defects (NTDs) nationallicence All-trans retinoic acid (atRA) nationallicence Neurulation nationallicence Hamartoma nationallicence Myeloschisis nationallicence Spina bifida nationallicence Currarino triad nationallicence Cai WeiSong Congenital Malformation Lab, Pediatric Surgery, The Second Affiliated Hospital (Shengjing Hospital), China Medical University, 36 Sanhao St. Heping District, 110004, Shenyang, People's Republic of China aut Zhao HongYu Neurosurgery, The Second Affiliated Hospital (Shengjing Hospital), China Medical University, 36 Sanhao St. Heping District, 110004, Shenyang, People's Republic of China aut Guo JunBin Congenital Malformation Lab, Pediatric Surgery, The Second Affiliated Hospital (Shengjing Hospital), China Medical University, 36 Sanhao St. Heping District, 110004, Shenyang, People's Republic of China aut Li Yong Congenital Malformation Lab, Pediatric Surgery, The Second Affiliated Hospital (Shengjing Hospital), China Medical University, 36 Sanhao St. Heping District, 110004, Shenyang, People's Republic of China aut Yuan ZhengWei Congenital Malformation Lab, Pediatric Surgery, The Second Affiliated Hospital (Shengjing Hospital), China Medical University, 36 Sanhao St. Heping District, 110004, Shenyang, People's Republic of China aut Wang WeiLin Congenital Malformation Lab, Pediatric Surgery, The Second Affiliated Hospital (Shengjing Hospital), China Medical University, 36 Sanhao St. Heping District, 110004, Shenyang, People's Republic of China aut Child's Nervous System Springer-Verlag 23/5(2007-05-01), 549-554 0256-7040 23:5<549 2007 23 381 https://doi.org/10.1007/s00381-006-0289-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00381-006-0289-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cai WeiSong Congenital Malformation Lab, Pediatric Surgery, The Second Affiliated Hospital (Shengjing Hospital), China Medical University, 36 Sanhao St. Heping District, 110004, Shenyang, People's Republic of China aut NATIONALLICENCE 700 1- Zhao HongYu Neurosurgery, The Second Affiliated Hospital (Shengjing Hospital), China Medical University, 36 Sanhao St. Heping District, 110004, Shenyang, People's Republic of China aut NATIONALLICENCE 700 1- Guo JunBin Congenital Malformation Lab, Pediatric Surgery, The Second Affiliated Hospital (Shengjing Hospital), China Medical University, 36 Sanhao St. Heping District, 110004, Shenyang, People's Republic of China aut NATIONALLICENCE 700 1- Li Yong Congenital Malformation Lab, Pediatric Surgery, The Second Affiliated Hospital (Shengjing Hospital), China Medical University, 36 Sanhao St. Heping District, 110004, Shenyang, People's Republic of China aut NATIONALLICENCE 700 1- Yuan ZhengWei Congenital Malformation Lab, Pediatric Surgery, The Second Affiliated Hospital (Shengjing Hospital), China Medical University, 36 Sanhao St. Heping District, 110004, Shenyang, People's Republic of China aut NATIONALLICENCE 700 1- Wang WeiLin Congenital Malformation Lab, Pediatric Surgery, The Second Affiliated Hospital (Shengjing Hospital), China Medical University, 36 Sanhao St. Heping District, 110004, Shenyang, People's Republic of China aut NATIONALLICENCE 773 0- Child's Nervous System Springer-Verlag 23/5(2007-05-01), 549-554 0256-7040 23:5<549 2007 23 381 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer