caa a22 4500 463180941 CHVBK 20180406164838.0 cr unu---uuuuu 170326e20070201xx s 000 0 eng 10.1007/s00381-006-0198-0 doi (NATIONALLICENCE)springer-10.1007/s00381-006-0198-0 Morphological pattern and frequency of intracranial tumors in children [Elektronische Daten] [M. Mehrazin, P. Yavari] Background: Brain tumors are the second most common neoplasm in children. Pattern of primary brain tumors in children has not been reported in Iran. Brain tumors have been the subject of controversy both with respect to pattern of occurrence and to potential causes. Objective: To determine the age, sex, location, and histologic diagnosis of intracranial tumors in children less than 15years of age. Materials and methods: A retrospective study of 619 children who were admitted to the neurosurgical center between 1978 and 2003 was performed. Charts were reviewed to extract information about demographics, location, and histopathological diagnosis of tumors. All patients entered into this study had pathologically proven brain tumor. The frequency distribution of brain tumors by age and sex, location, and histopathology was calculated. Results: The male-female ratio, 58.1 to 41.9%, vary significantly (p<0.05). The mean age of the patients at time of diagnosis was 8.8years (SD=3.9). Fifty-one percent of brain tumors were located in supratentorial, and 49.0% in the infratentorial region. In supratentorial region, 57.0% of the tumors were in the hemispheric. In infratentorial region, 68% of the tumors were in the midline. The mixed five most common histological diagnoses in patients were astrocytoma (40.4%), followed by medulloblastoma (18.4%), ependymoma (10.5%), craniopharyngioma (8.8%), and meningioma (4.2%). Most of the brain tumor types (85%) occurred in children between 5 to 15years of age. Astrocytoma occurred mostly in children aged 5-15years (87%). Conclusion: Males were affected more than females. A significant male predominance was observed in craniopharyngioma and medulloblastoma. Astrocytoma was the first most common brain tumor in all age groups. Certain tumor types show a predilection for the certain period of life. Springer-Verlag, 2006 Epidemiology nationallicence Brain tumors nationallicence Children nationallicence Location nationallicence Histopathology nationallicence Mehrazin M. Department of Neurosurgery, Tehran University of Medical Sciences, Shariati Hospital, Tehran, Iran aut Yavari P. Department of Health and Community Medicine, Shaheed Beheshti University of Medical Sciences, Evin, Tehran, Iran aut Child's Nervous System Springer-Verlag 23/2(2007-02-01), 157-162 0256-7040 23:2<157 2007 23 381 https://doi.org/10.1007/s00381-006-0198-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00381-006-0198-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mehrazin M. Department of Neurosurgery, Tehran University of Medical Sciences, Shariati Hospital, Tehran, Iran aut NATIONALLICENCE 700 1- Yavari P. Department of Health and Community Medicine, Shaheed Beheshti University of Medical Sciences, Evin, Tehran, Iran aut NATIONALLICENCE 773 0- Child's Nervous System Springer-Verlag 23/2(2007-02-01), 157-162 0256-7040 23:2<157 2007 23 381 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer