caa a22 4500 463181069 CHVBK 20180406164839.0 cr unu---uuuuu 170326e20070201xx s 000 0 eng 10.1007/s00381-006-0213-5 doi (NATIONALLICENCE)springer-10.1007/s00381-006-0213-5 Trimyelia with divergent cord pathways and three foramina magni [Elektronische Daten] [Glenn Sandberg, Kondi Wong, Iren Horkayne-Szakaly, Glenn Dickey, Lucy Rorke-Adams, Elisabeth Rushing] Object: We report the rare finding of trimyelia with divergent cord pathways in a 33 5/7-week-old fetus who died shortly after spontaneous vaginal delivery. Methods: The main autopsy findings were three separate and distinct spinal cords, arising from the medulla and exiting through three separate foramina magni. The two lateral cords coursed toward each upper extremity and the medulla split into two halves that rejoined to form a central cervical cord. Further evaluation of this anomaly revealed agenesis of the cerebellar vermis and cystic dilation of the fourth ventricle. Microscopic cross-sections of the two lateral cords demonstrated well-formed central canals, white matter, and central gray with motor neurons. Sections of the abnormal mid-cervical cord demonstrated abnormally structured cord parenchyma without central canals. Conclusions: Some features were consistent with iniencephaly; however, defects of the occipital bone, anterior spina bifida, and shortening of the spinal cord were absent. Although agenesis of the cerebellar vermis and cystic dilation of the fourth ventricle indicate Dandy-Walker syndrome, other features such as hydrocephalus, agenesis of the corpus callosum, infundibular hamartomas, and malformations of the inferior olives or an occipital encephalocele were absent. The possible pathogenesis of this intriguing pathological entity is briefly discussed. Springer-Verlag, 2006 Agenesis nationallicence Cerebellum nationallicence Dandy-Walker syndrome nationallicence Iniencephaly nationallicence Malformation nationallicence Spinal cord nationallicence Trimyelia nationallicence Sandberg Glenn Department of Neuropathology and Ophthalmic Pathology, Armed Forces Institute of Pathology, 20306-6000, Washington, DC, USA aut Wong Kondi Department of Neuropathology and Ophthalmic Pathology, Armed Forces Institute of Pathology, 20306-6000, Washington, DC, USA aut Horkayne-Szakaly Iren Department of Neuropathology and Ophthalmic Pathology, Armed Forces Institute of Pathology, 20306-6000, Washington, DC, USA aut Dickey Glenn Pediatric Pathology, Armed Forces Institute of Pathology, Washington, DC, USA aut Rorke-Adams Lucy Department of Pathology, Children's Hospital of Philadelphia, Philadelphia, PA, USA aut Rushing Elisabeth Department of Neuropathology and Ophthalmic Pathology, Armed Forces Institute of Pathology, 20306-6000, Washington, DC, USA aut Child's Nervous System Springer-Verlag 23/2(2007-02-01), 249-253 0256-7040 23:2<249 2007 23 381 https://doi.org/10.1007/s00381-006-0213-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00381-006-0213-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sandberg Glenn Department of Neuropathology and Ophthalmic Pathology, Armed Forces Institute of Pathology, 20306-6000, Washington, DC, USA aut NATIONALLICENCE 700 1- Wong Kondi Department of Neuropathology and Ophthalmic Pathology, Armed Forces Institute of Pathology, 20306-6000, Washington, DC, USA aut NATIONALLICENCE 700 1- Horkayne-Szakaly Iren Department of Neuropathology and Ophthalmic Pathology, Armed Forces Institute of Pathology, 20306-6000, Washington, DC, USA aut NATIONALLICENCE 700 1- Dickey Glenn Pediatric Pathology, Armed Forces Institute of Pathology, Washington, DC, USA aut NATIONALLICENCE 700 1- Rorke-Adams Lucy Department of Pathology, Children's Hospital of Philadelphia, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Rushing Elisabeth Department of Neuropathology and Ophthalmic Pathology, Armed Forces Institute of Pathology, 20306-6000, Washington, DC, USA aut NATIONALLICENCE 773 0- Child's Nervous System Springer-Verlag 23/2(2007-02-01), 249-253 0256-7040 23:2<249 2007 23 381 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer