caa a22 4500 463181085 CHVBK 20180406164839.0 cr unu---uuuuu 170326e20070201xx s 000 0 eng 10.1007/s00381-006-0177-5 doi (NATIONALLICENCE)springer-10.1007/s00381-006-0177-5 Giant prolactinomas in adolescence: an uncommon cause of blindness [Elektronische Daten] [Patrick Semple, Graham Fieggen, Jeannette Parkes, Naomi Levitt] Introduction: Prolactinomas in childhood and adolescence are rare. However, in male patients in particular they may become extremely large and invasive, resulting in visual impairment without necessarily producing endocrine symptoms. Case reports: We report on two adolescent males who presented with deteriorating vision over a long period of time and who had optic atrophy on examination. Magnetic resonance imaging identified tumours with extensive anterior skull base invasion and suprasellar extension. Prolactin levels in both patients were markedly elevated, and a diagnosis of prolactinoma was made. Bromocriptine treatment was started resulting in lowered prolactin levels, improved vision and tumour shrinkage on imaging. Conclusion: A male child or adolescent presenting with diminished vision and found to have suprasellar or anterior skull base tumour should have their prolactin levels checked to rule out a prolactinoma, which can be successfully managed with medical therapy. Springer-Verlag, 2006 Prolactinoma nationallicence Blindness nationallicence Childhood nationallicence Adolescence nationallicence Semple Patrick OH 53 OMB, Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa aut Fieggen Graham OH 53 OMB, Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa aut Parkes Jeannette OH 53 OMB, Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa aut Levitt Naomi OH 53 OMB, Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa aut Child's Nervous System Springer-Verlag 23/2(2007-02-01), 213-217 0256-7040 23:2<213 2007 23 381 https://doi.org/10.1007/s00381-006-0177-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00381-006-0177-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Semple Patrick OH 53 OMB, Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa aut NATIONALLICENCE 700 1- Fieggen Graham OH 53 OMB, Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa aut NATIONALLICENCE 700 1- Parkes Jeannette OH 53 OMB, Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa aut NATIONALLICENCE 700 1- Levitt Naomi OH 53 OMB, Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa aut NATIONALLICENCE 773 0- Child's Nervous System Springer-Verlag 23/2(2007-02-01), 213-217 0256-7040 23:2<213 2007 23 381 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer