caa a22 4500 463181123 CHVBK 20180406164839.0 cr unu---uuuuu 170326e20070201xx s 000 0 eng 10.1007/s00381-006-0197-1 doi (NATIONALLICENCE)springer-10.1007/s00381-006-0197-1 Sequential analysis of cadherin expression in a 4-year-old girl with intracranial ependymoma [Elektronische Daten] [Kentaro Yokoi, Masaharu Akiyama, Takaaki Yanagisawa, Junko Takahashi-Fujigasaki, Yuichi Yokokawa, Yoko Mikami-Terao, Kohei Fukuoka, Kohji Fujisawa, Hiromichi Nakazaki, Shizuo Oi, Yoshikatsu Eto, Hisashi Yamada] Introduction: Cadherins are Ca2+-dependent cell-to-cell adhesion molecules that play an important role in tissue construction and morphogenesis in multicellular organisms. Cadherin involvement in tumor metastasis has recently been reported. Case report: We investigated the expression of E-cadherin and N-cadherin in paraffin-embedded sequential surgical specimens and autopsy specimens from a 4-year-old girl with recurrent ependymoma, subsequent to cerebrospinal fluid (CSF) dissemination. We observed low expression of E-cadherin in all surgical specimens and autopsy specimens. In contrast, expression of N-cadherin was high in all surgical specimens, but was decreased in autopsy specimens. Conclusion: Decreased expression of N-cadherin may be associated with CSF dissemination and may serve as a useful marker for CSF dissemination in patients with intracranial ependymoma. Springer-Verlag, 2006 Ependymoma nationallicence Recurrence nationallicence Dissemination nationallicence N-cadherin nationallicence Yokoi Kentaro Department of Pediatrics, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, 105-8461, Minato-ku, Tokyo, Japan aut Akiyama Masaharu Department of Pediatrics, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, 105-8461, Minato-ku, Tokyo, Japan aut Yanagisawa Takaaki Department of Pediatrics, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, 105-8461, Minato-ku, Tokyo, Japan aut Takahashi-Fujigasaki Junko Division of Neuropathology, Jikei University School of Medicine, Tokyo, Japan aut Yokokawa Yuichi Department of Pediatrics, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, 105-8461, Minato-ku, Tokyo, Japan aut Mikami-Terao Yoko Department of Pediatrics, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, 105-8461, Minato-ku, Tokyo, Japan aut Fukuoka Kohei Department of Pediatrics, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, 105-8461, Minato-ku, Tokyo, Japan aut Fujisawa Kohji Department of Pediatrics, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, 105-8461, Minato-ku, Tokyo, Japan aut Nakazaki Hiromichi Department of Pediatric Neurosurgery, Jikei University School of Medicine, Tokyo, Japan aut Oi Shizuo Department of Pediatric Neurosurgery, Jikei University School of Medicine, Tokyo, Japan aut Eto Yoshikatsu Department of Pediatrics, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, 105-8461, Minato-ku, Tokyo, Japan aut Yamada Hisashi Department of Molecular Genetics, Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, Japan aut Child's Nervous System Springer-Verlag 23/2(2007-02-01), 237-242 0256-7040 23:2<237 2007 23 381 https://doi.org/10.1007/s00381-006-0197-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00381-006-0197-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yokoi Kentaro Department of Pediatrics, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, 105-8461, Minato-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Akiyama Masaharu Department of Pediatrics, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, 105-8461, Minato-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Yanagisawa Takaaki Department of Pediatrics, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, 105-8461, Minato-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Takahashi-Fujigasaki Junko Division of Neuropathology, Jikei University School of Medicine, Tokyo, Japan aut NATIONALLICENCE 700 1- Yokokawa Yuichi Department of Pediatrics, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, 105-8461, Minato-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Mikami-Terao Yoko Department of Pediatrics, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, 105-8461, Minato-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Fukuoka Kohei Department of Pediatrics, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, 105-8461, Minato-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Fujisawa Kohji Department of Pediatrics, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, 105-8461, Minato-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Nakazaki Hiromichi Department of Pediatric Neurosurgery, Jikei University School of Medicine, Tokyo, Japan aut NATIONALLICENCE 700 1- Oi Shizuo Department of Pediatric Neurosurgery, Jikei University School of Medicine, Tokyo, Japan aut NATIONALLICENCE 700 1- Eto Yoshikatsu Department of Pediatrics, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, 105-8461, Minato-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Yamada Hisashi Department of Molecular Genetics, Institute of DNA Medicine, Jikei University School of Medicine, Tokyo, Japan aut NATIONALLICENCE 773 0- Child's Nervous System Springer-Verlag 23/2(2007-02-01), 237-242 0256-7040 23:2<237 2007 23 381 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer