caa a22 4500 463185234 CHVBK 20180406164851.0 cr unu---uuuuu 170326e20070101xx s 000 0 eng 10.1007/s00726-005-0292-8 doi (NATIONALLICENCE)springer-10.1007/s00726-005-0292-8 Abnormal changes of plasma acute phase proteins in schizophrenia and the relation between schizophrenia and haptoglobin (Hp) gene [Elektronische Daten] [C. Wan, Y. La, H. Zhu, Y. Yang, L. Jiang, Y. Chen, G. Feng, H. Li, H. Sang, X. Hao, G. Zhang, L. He] Summary.: In this study we focused on detecting schizophrenia related changes of plasma proteins using proteomic technology and examining the relation between schizophrenia and haptoglobin (Hp) genotype. We investigated plasma proteins from schizophrenic subjects (n = 42) and healthy controls (n = 46) by two-dimensional gel electrophoresis (2-DE) in combination with mass spectrometry. To further reveal the genetic relationship between acute phase proteins (APPs) and schizophrenia disease, we tested Hp α1/Hp α2 (Hp 1/2) polymorphism and two single nucleotide polymorphisms (SNPs) of Hp, rs2070937 and rs5473, for associations with schizophrenia in the Chinese Han population. With the relatively high number of samples for 2-DE work, we found that four proteins in the family of positive APPs were all up-regulated in patients. In genetic association study, we found significant associations existing between schizophrenia and Hp polymorphisms, Hp 1/2 and rs2070937 variants. Schizophrenia is accompanied by both an altered expression of Hp protein and a different genotype distribution of Hp gene, demonstrating that Hp is associated with schizophrenia. The results from proteomic and genomic aspects both indicate that acute phase reaction is likely to be an aetiological agent in the pathophysiology of schizophrenia, but not just an accompanying symptom. The positive APPs are schizophrenic related proteins, with the highly concordant results on four positive APPs. Springer-Verlag, 2006 Keywords: Schizophrenia - Acute phase proteins - Proteomics - Plasma - Haptoglobin nationallicence Wan C. Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, China aut La Y. Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, China aut Zhu H. Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, China aut Yang Y. Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, China aut Jiang L. Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, China aut Chen Y. Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, China aut Feng G. Shanghai Institute of Mental Health, Shanghai, China aut Li H. Shanghai Institute of Mental Health, Shanghai, China aut Sang H. Kaixuan Hospital of Changchun, Jilin Province, China aut Hao X. Kaixuan Hospital of Changchun, Jilin Province, China aut Zhang G. Shanghai Zhabei Institute of Mental Health, Shanghai, China aut He L. Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, China aut Amino Acids Springer-Verlag 32/1(2007-01-01), 101-108 0939-4451 32:1<101 2007 32 726 https://doi.org/10.1007/s00726-005-0292-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-005-0292-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wan C. Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, China aut NATIONALLICENCE 700 1- La Y. Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, China aut NATIONALLICENCE 700 1- Zhu H. Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, China aut NATIONALLICENCE 700 1- Yang Y. Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, China aut NATIONALLICENCE 700 1- Jiang L. Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, China aut NATIONALLICENCE 700 1- Chen Y. Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, China aut NATIONALLICENCE 700 1- Feng G. Shanghai Institute of Mental Health, Shanghai, China aut NATIONALLICENCE 700 1- Li H. Shanghai Institute of Mental Health, Shanghai, China aut NATIONALLICENCE 700 1- Sang H. Kaixuan Hospital of Changchun, Jilin Province, China aut NATIONALLICENCE 700 1- Hao X. Kaixuan Hospital of Changchun, Jilin Province, China aut NATIONALLICENCE 700 1- Zhang G. Shanghai Zhabei Institute of Mental Health, Shanghai, China aut NATIONALLICENCE 700 1- He L. Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, China aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 32/1(2007-01-01), 101-108 0939-4451 32:1<101 2007 32 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer