caa a22 4500 463185269 CHVBK 20180406164851.0 cr unu---uuuuu 170326e20070101xx s 000 0 eng 10.1007/s00726-006-0443-6 doi (NATIONALLICENCE)springer-10.1007/s00726-006-0443-6 Focus on phosphohistidine [Elektronische Daten] [P. V. Attwood, M. J. Piggott, X. L. Zu, P. G. Besant] Summary.: Phosphohistidine has been identified as an enzymic intermediate in numerous biochemical reactions and plays a functional role in many regulatory pathways. Unlike the phosphoester bond of its cousins (phosphoserine, phosphothreonine and phosphotyrosine), the phosphoramidate (P-N) bond of phosphohistidine has a high ΔG° of hydrolysis and is unstable under acidic conditions. This acid-lability has meant that the study of protein histidine phosphorylation and the associated protein kinases has been slower to progress than other protein phosphorylation studies. Histidine phosphorylation is a crucial component of cell signalling in prokaryotes and lower eukaryotes. It is also now becoming widely reported in mammalian signalling pathways and implicated in certain human disease states. This review covers the chemistry of phosphohistidine in terms of its isomeric forms and chemical derivatives, how they can be synthesized, purified, identified and the relative stabilities of each of these forms. Furthermore, we highlight how this chemistry relates to the role of phosphohistidine in its various biological functions. Springer-Verlag, 2006 Keywords: Phosphohistidine - Histidine kinase - Phosphoramidate nationallicence Attwood P. V. School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Perth, Australia aut Piggott M. J. School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Perth, Australia aut Zu X. L. School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Perth, Australia aut Besant P. G. School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Perth, Australia aut Amino Acids Springer-Verlag 32/1(2007-01-01), 145-156 0939-4451 32:1<145 2007 32 726 https://doi.org/10.1007/s00726-006-0443-6 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-006-0443-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Attwood P. V. School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Perth, Australia aut NATIONALLICENCE 700 1- Piggott M. J. School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Perth, Australia aut NATIONALLICENCE 700 1- Zu X. L. School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Perth, Australia aut NATIONALLICENCE 700 1- Besant P. G. School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Perth, Australia aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 32/1(2007-01-01), 145-156 0939-4451 32:1<145 2007 32 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer