caa a22 4500 463185277 CHVBK 20180406164851.0 cr unu---uuuuu 170326e20070101xx s 000 0 eng 10.1007/s00726-005-0356-9 doi (NATIONALLICENCE)springer-10.1007/s00726-005-0356-9 Effects of D-amino acids on lipoperoxidation in rat liver and kidney mitochondria [Elektronische Daten] [C. Cortés-Rojo, M. Clemente-Guerrero, A. Saavedra-Molina] Summary.: The effects of the amino acids D-ser, D-asp, and D-ala on lipoperoxidation under conditions of hypertension, alcoholism, and ammonemia in rat liver and kidney mitochondria were studied. Under normal conditions, D-alanine increased in 54% free radicals production in liver mitochondria (p < 0.05). The D-amino acids had no effect on kidney mitochondria. D-ser and D-ala increased lipoperoxidation in spontaneously hypertensive rats (SHR) as compared with their normotensive genetic control Wistar-Kyoto (WKY) rats (p < 0.05). During hypertension and in oxidative stress in the presence of calcium, only D-ala produced 46% and 29% free radicals in liver and kidney mitochondria (p < 0.05), respectively. During chronic alcoholism, D-ser increased lipoperoxidation in 80% in kidney mitochondria (p < 0.05), as compared to control. During ammonemia, D-ser produced 41% free radicals. Springer-Verlag, 2006 Keywords: Lipoperoxidation - D-amino acids - Hypertension - Oxidative stress - Chronic alcoholism - Liver mitochondria - Kidney mitochondria nationallicence Cortés-Rojo C. Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, México aut Clemente-Guerrero M. Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, México aut Saavedra-Molina A. Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, México aut Amino Acids Springer-Verlag 32/1(2007-01-01), 31-37 0939-4451 32:1<31 2007 32 726 https://doi.org/10.1007/s00726-005-0356-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-005-0356-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cortés-Rojo C. Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, México aut NATIONALLICENCE 700 1- Clemente-Guerrero M. Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, México aut NATIONALLICENCE 700 1- Saavedra-Molina A. Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, México aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 32/1(2007-01-01), 31-37 0939-4451 32:1<31 2007 32 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer