caa a22 4500 463185307 CHVBK 20180406164851.0 cr unu---uuuuu 170326e20070101xx s 000 0 eng 10.1007/s00726-006-0284-3 doi (NATIONALLICENCE)springer-10.1007/s00726-006-0284-3 Influence of pegylated interferon-α therapy on plasma levels of citrulline and arginine in melanoma patients [Elektronische Daten] [D. Fekkes, M. Bannink, W. H. J. Kruit, A. R. Van Gool, P. G. H. Mulder, S. Sleijfer, A. M. M. Eggermont, G. Stoter] Summary.: The aim of this study was to evaluate the effect of pegylated interferon-alpha (PEG-IFN-α) on the plasma citrulline/arginine ratio, regarded as an index of nitric oxide (NO) synthesis, in patients with high-risk melanoma. Forty patients were randomly assigned to either PEG-IFN-α treatment (n = 22) or to observation only (control group, n = 18). The treatment group received 6 µg PEG-IFN-α/kg once a week during 8 weeks, followed by a maintenance dose of 3 µg/kg/wk. Blood was collected at different time points, plasma concentrations of citrulline and arginine were measured and the ratio of citrulline/arginine was calculated. Patients treated with PEG-IFN-α showed a significant decrease in the concentrations of citrulline and in the citrulline/arginine ratio during the whole study period, both compared to baseline values and to the control group. The data suggest that therapy with PEG-IFN-α results in a marked decrease in the synthesis of NO in melanoma patients. Springer-Verlag, 2006 Keywords: Interferon - Nitric oxide - Melanoma - Citrulline - Arginine nationallicence Fekkes D. Department of Neuroscience, Erasmus MC, The Netherlands aut Bannink M. Department of Psychiatry, Erasmus MC - Daniel den Hoed Cancer Center, The Netherlands aut Kruit W. H. J. Department of Medical Oncology, Erasmus MC - Daniel den Hoed Cancer Center, The Netherlands aut Van Gool A. R. Department of Psychiatry, Erasmus MC - Daniel den Hoed Cancer Center, The Netherlands aut Mulder P. G. H. Department of Epidemiology and Biostatistics, Erasmus MC, The Netherlands aut Sleijfer S. Department of Medical Oncology, Erasmus MC - Daniel den Hoed Cancer Center, The Netherlands aut Eggermont A. M. M. Department of Surgical Oncology, Erasmus MC - Daniel den Hoed Cancer Center, The Netherlands aut Stoter G. Department of Medical Oncology, Erasmus MC - Daniel den Hoed Cancer Center, The Netherlands aut Amino Acids Springer-Verlag 32/1(2007-01-01), 121-126 0939-4451 32:1<121 2007 32 726 https://doi.org/10.1007/s00726-006-0284-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00726-006-0284-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fekkes D. Department of Neuroscience, Erasmus MC, The Netherlands aut NATIONALLICENCE 700 1- Bannink M. Department of Psychiatry, Erasmus MC - Daniel den Hoed Cancer Center, The Netherlands aut NATIONALLICENCE 700 1- Kruit W. H. J. Department of Medical Oncology, Erasmus MC - Daniel den Hoed Cancer Center, The Netherlands aut NATIONALLICENCE 700 1- Van Gool A. R. Department of Psychiatry, Erasmus MC - Daniel den Hoed Cancer Center, The Netherlands aut NATIONALLICENCE 700 1- Mulder P. G. H. Department of Epidemiology and Biostatistics, Erasmus MC, The Netherlands aut NATIONALLICENCE 700 1- Sleijfer S. Department of Medical Oncology, Erasmus MC - Daniel den Hoed Cancer Center, The Netherlands aut NATIONALLICENCE 700 1- Eggermont A. M. M. Department of Surgical Oncology, Erasmus MC - Daniel den Hoed Cancer Center, The Netherlands aut NATIONALLICENCE 700 1- Stoter G. Department of Medical Oncology, Erasmus MC - Daniel den Hoed Cancer Center, The Netherlands aut NATIONALLICENCE 773 0- Amino Acids Springer-Verlag 32/1(2007-01-01), 121-126 0939-4451 32:1<121 2007 32 726 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer